Leishmanicidal Activity of Two Naphthoquinones against Leishmania donovani

Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values comp...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2012/10/01, Vol.35(10), pp.1761-1764
Main Authors: Lezama-Dávila, Claudio Manuel, Isaac-Márquez, Angelica Patricia, Kapadia, Govind, Owens, Katherine, Oghumu, Steve, Beverley, Stephen, Satoskar, Abhay Rajaninath
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Cells, Cultured
Indexing in process
Leishmania
Leishmania donovani - drug effects
macrophage
Macrophages - drug effects
Macrophages - metabolism
Mice
Mice, Inbred C57BL
naphthoquinone
Naphthoquinones - pharmacology
Nitric Oxide - metabolism
Trypanocidal Agents - pharmacology
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Summary:Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b12-00419