A modified glucomannan mycotoxin-adsorbing agent counteracts the reduced weight gain and diminishes cecal colonization of Salmonella Typhimurium in T-2 toxin exposed pigs

The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23days: (1) free of mycotoxins, (2) containing 1g binder per kg feed, (3) containing 83μg T-2 toxin per kg f...

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Bibliographic Details
Published in:Research in veterinary science 2012-12, Vol.93 (3), p.1139-1141
Main Authors: Verbrugghe, Elin, Croubels, Siska, Vandenbroucke, Virginie, Goossens, Joline, De Backer, Patrick, Eeckhout, Mia, De Saeger, Sarah, Boyen, Filip, Leyman, Bregje, Van Parys, Alexander, Haesebrouck, Freddy, Pasmans, Frank
Format: Article
Language:English
Subjects:
Adsorption
Animal Feed - analysis
Animals
Bacteria
Binder
cecum
Cecum - microbiology
Colonization
Diet
Diet - veterinary
feed contamination
Food Contamination
Glucomannan
glucomannans
Hogs
Mannans - chemistry
Mycotoxins
Pigs
Salmonella
Salmonella Infections, Animal - microbiology
Salmonella Infections, Animal - prevention & control
Salmonella typhimurium
Salmonella typhimurium - drug effects
Swine
Swine Diseases - prevention & control
T-2 toxin
T-2 Toxin - toxicity
Veterinary medicine
weight gain
Weight Gain - drug effects
weight loss
Yeast
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Summary:The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23days: (1) free of mycotoxins, (2) containing 1g binder per kg feed, (3) containing 83μg T-2 toxin per kg feed and (4) containing 83μg T-2 toxin and 1g binder per kg feed. After 18days, all pigs were inoculated with Salmonella Typhimurium and euthanized five days later. The addition of the binder to T-2 toxin contaminated feed counteracted the reduced weight gain of pigs caused by T-2 toxin and reduced the amount of Salmonella Typhimurium in the cecum and cecal contents. In vitro findings might indicate that the binder captures Salmonella. We thus conclude that the binder counteracts T-2 toxin induced weight loss and possibly binds Salmonella, resulting in a reduced cecal colonization.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2012.07.007