Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells

In this study we propose a novel anticancer agent using hetero-chitooligosaccharide (hetero-COS). To examine the possibility of the hetero-COS as a anticancer agent, we prepared nine kinds of hetero-COS with relatively higher molecular weights (90, 75 and 50-COS I, 5-10kDa), medium molecular weights...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2012-10, Vol.22 (19), p.6136-6138
Main Authors: Kim, Eun-Kyung, Je, Jae-Young, Lee, Seung-Jae, Kim, Yon-Suk, Hwang, Jin-Woo, Sung, Si-Heung, Moon, Sang-Ho, Jeon, Byong-Tae, Kim, Se-Kwon, Jeon, You-Jin, Park, Pyo-Jam
Format: Article
Language:English
Subjects:
Anticancer
anticarcinogenic activity
antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
apoptosis
Apoptosis - drug effects
Biological and medical sciences
Carbohydrate Conformation
chitooligosaccharides
Deacetylation
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
flow cytometry
Hetero-chitooligosaccharide
HL-60 Cells
Humans
Indexing in process
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - pathology
Medical sciences
Molecular Weight
myeloid leukemia
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:In this study we propose a novel anticancer agent using hetero-chitooligosaccharide (hetero-COS). To examine the possibility of the hetero-COS as a anticancer agent, we prepared nine kinds of hetero-COS with relatively higher molecular weights (90, 75 and 50-COS I, 5-10kDa), medium molecular weights (90, 75 and 50-COS II, 1-5kDa), and lower molecular weights (90, 75 and 50-III, below 1kDa), and their anticancer properties were investigated on HL-60 cells using flow cytometry and morphological analysis. The results obtained indicate that 90-COS III, which is relatively higher degree of deacetylation and lower molecular weights, showed the highest anticancer activity, and the data showed the anticancer property of the hetero-COSs depended on their degree of deacetylation values and molecular weight.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2012.08.030