Hodgkin's lymphoma in adults

Management of Hodgkin's lymphoma continues to develop. Outcomes for patients with favourable-risk, early-stage disease are excellent, and serial reductions in intensity of treatment have been made to retain the excellent prognosis while reducing the late effects of treatment. Prognosis is also...

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Bibliographic Details
Published in:The Lancet (British edition) 2012-09, Vol.380 (9844), p.836-847
Main Authors: Townsend, William, MBChB, Linch, David, Prof
Format: Article
Language:English
Subjects:
Adult
adults
Biological and medical sciences
Combined Modality Therapy
General aspects
Hematologic and hematopoietic diseases
Hodgkin disease
Hodgkin Disease - diagnosis
Hodgkin Disease - epidemiology
Hodgkin Disease - pathology
Hodgkin Disease - therapy
Humans
image analysis
Internal Medicine
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Neoplasm Staging
patients
Positron-Emission Tomography
Prognosis
Recurrence
relapse
Salvage Therapy - methods
Treatment Outcome
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Summary:Management of Hodgkin's lymphoma continues to develop. Outcomes for patients with favourable-risk, early-stage disease are excellent, and serial reductions in intensity of treatment have been made to retain the excellent prognosis while reducing the late effects of treatment. Prognosis is also very good in advanced-stage disease but the rate of relapse is higher than in early-stage disease, and the optimum first-line treatment is unclear. Workers are investigating the role of functional imaging to assess whether treatment can be tailored according to response, with the most intensive therapies reserved for patients predicted to have poor outcomes. In this Seminar we critically appraise the management of Hodgkin's lymphoma in early-stage disease, advanced-stage disease, and at relapse, with a focus on late effects of treatment.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(12)60035-X