Early Increases in Soluble Amyloid- Levels Coincide with Cholinergic Degeneration in 3xTg-AD Mice

Accumulation of amyloid- peptides (A) and cholinergic degeneration are hallmarks of Alzheimers disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble A42 levels were detected in the septum by 2 months of age, reaching their highest levels at 36 months and decreasing at 12 months....

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Published in:Journal of Alzheimer's disease 2012-01, Vol.32 (2), p.267-272
Main Authors: Jordo, Jessica, Ypsilanti, Athna, McLaurin, JoAnne, Aubert, Isabelle
Format: Article
Language:English
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Summary:Accumulation of amyloid- peptides (A) and cholinergic degeneration are hallmarks of Alzheimers disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble A42 levels were detected in the septum by 2 months of age, reaching their highest levels at 36 months and decreasing at 12 months. Deficits in the number of septal cholinergic neurons and the length of hippocampal cholinergic axons were observed starting at 4 months in 3xTg-AD mice. Our results show that septal A and septohippocampal cholinergic pathology in 3xTg-AD mice occur at an early stage of disease.
ISSN:1387-2877