Activity and synergistic interactions of stilbenes and antibiotic combinations against bacteria in vitro

The synergistic antibacterial activity of two stilbenes [3,4′,5-trihydroxystilbene (1) and 3,5-dihydroxy-4-isopropylstilbene(2)] purified from a Bacillus sp. N strain associated with entomopathogenic nematode Rhabditis ( Oscheius ) in combination with ciprofloxacin and cefotaxime was investigated. T...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2012-11, Vol.28 (11), p.3143-3150
Main Authors: Kumar, S. Nishanth, Siji, J. V., Nambisan, Bala, Mohandas, C.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Applied Microbiology
Bacillus
Bacillus - chemistry
Bacillus - isolation & purification
Bacteria
Bacteria - drug effects
Bacterial infections
Biochemistry
Biomedical and Life Sciences
Biotechnology
Combination therapy
Drug resistance
Drug Synergism
Environmental Engineering/Biotechnology
Gram-negative bacteria
Gram-positive bacteria
Life Sciences
Metabolites
Microbial Sensitivity Tests
Microbial Viability - drug effects
Microbiology
Microorganisms
Natural products
Nematoda
Original Paper
Pathogens
Phenols
Rhabditis
Rhabditoidea - microbiology
Stilbenes - isolation & purification
Stilbenes - pharmacology
Studies
Synergistic effect
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Summary:The synergistic antibacterial activity of two stilbenes [3,4′,5-trihydroxystilbene (1) and 3,5-dihydroxy-4-isopropylstilbene(2)] purified from a Bacillus sp. N strain associated with entomopathogenic nematode Rhabditis ( Oscheius ) in combination with ciprofloxacin and cefotaxime was investigated. The activity of the stilbenes and standard antibiotics on bacteria were determined using the macrodilution method. The minimum inhibitory concentration and minimum bactericidal concentration of the stilbenes was compared with that of the standard antibiotics. The antibacterial activities of stilbenes against pathogenic bacteria were assessed using the checkerboard and time-kill methods to evaluate the synergistic effects of stilbenes in treatment with ciprofloxacin or cefotaxime. The results of the present study showed that the combination effects of both stilbenes with ciprofloxacin were synergistic (FIC index
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-012-1124-0