White matter lesions and depression in patients with Parkinson's disease

Abstract Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatolog...

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Bibliographic Details
Published in:Journal of the neurological sciences 2012-11, Vol.322 (1), p.132-136
Main Authors: Petrovic, Igor N, Stefanova, Elka, Kozic, Dusko, Semnic, Robert, Markovic, Vladana, Daragasevic, Natasa T, Kostic, Vladimir S
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Brain - pathology
Depression
Depressive Disorder - complications
Depressive Disorder - diagnosis
Female
Humans
Image Processing, Computer-Assisted
Indexing in process
Leukoencephalopathies - complications
Leukoencephalopathies - diagnosis
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Fibers, Myelinated - pathology
Neurology
Parkinson Disease - complications
Parkinson's disease
Psychiatric Status Rating Scales
White matter changes
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Summary:Abstract Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investigated whether WMHs were associated with depression in PD patients with disease onset above the age of 60. Thirty-four patients, with (PD-D) and 25 without depression (PD-nD), and 30 healthy age- and sex-matched controls were analyzed using the Scheltens visual rating scale. Cerebrovascular risk factors were similar across groups. Comparing controls and PD patients as a group there were no differences in WMHs in any examined regions. However, PD-D group had more common frontal WMHs although WMHs score didn't rich statistical significance. The same came true for total deep white matter changes comparing those two groups. In addition PD-D group had a significantly higher score for periventricular regions WMHs comparing with both PD-nD group and controls.PD-D group had significantly higher WMHs scores BG regions when compared to controls. The only significance in multivariate analyses was shown for periventricular WMHs total score explaining the 39% of the variance in the depressive score. Our findings suggest that WMH in the deep white matter may contribute to depression in PD.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2012.07.021