Genetic Risk Factors for Multiple Sclerosis in the Population of the Altai District

A case-control study in the Russian population of the Altai District showed that increased risk of multiple sclerosis was associated with DR15 and DR3 and the combination of the female gender and the A allele of the rs1800629 TNF α gene. There was no association between the occurrence of this diseas...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2012-10, Vol.42 (8), p.876-879
Main Authors: Smagina, I. V., Elchaninova, S. A., Zolovkina, A. G., Ignatova, Yu. N., Kudryavtseva, E. A.
Format: Article
Language:English
Subjects:
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
CD40 antigen
Disease
Gender
Gene polymorphism
Genes
Genotype & phenotype
Health risk assessment
Hospitals
Lymphocytes
Multiple sclerosis
Nervous system
Neurobiology
Neurosciences
Physiology
Population genetics
Regression analysis
Risk factors
Tumor necrosis factor- alpha
Tumor necrosis factor-TNF
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Summary:A case-control study in the Russian population of the Altai District showed that increased risk of multiple sclerosis was associated with DR15 and DR3 and the combination of the female gender and the A allele of the rs1800629 TNF α gene. There was no association between the occurrence of this disease and polymorphism of the CD40 gene (rs60764022).
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-012-9652-5