A study of changes in bone metabolism in cases of gender identity disorder

The aim of this study was to determine the effect of increasing estrogen and decreasing androgen in males and increasing androgen and decreasing estrogen in females on bone metabolism in patients with gender identity disorder (GID). We measured and examined bone mineral density (BMD) and bone metabo...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2012-07, Vol.30 (4), p.468-473
Main Authors: Miyajima, Tsuyoshi, Kim, Yoon Taek, Oda, Hiromi
Format: Article
Language:English
Subjects:
Adult
Aging
Androgen Antagonists - adverse effects
Androgens - adverse effects
Androgens - blood
Biological and medical sciences
Biomarkers - blood
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone Density - drug effects
Bone Resorption - chemically induced
Bone Resorption - prevention & control
Diphosphonates - therapeutic use
Diseases of the osteoarticular system
Estrogen Antagonists - adverse effects
Estrogens - adverse effects
Estrogens - blood
Estrogens - therapeutic use
Female
Humans
Indexing in process
Investigative techniques, diagnostic techniques (general aspects)
Japan
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Orthopedics
Osteoarticular system. Muscles
Osteoporosis - chemically induced
Osteoporosis - drug therapy
Osteoporosis - prevention & control
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Retrospective Studies
Sex Reassignment Procedures - adverse effects
Transsexualism - blood
Transsexualism - complications
Transsexualism - metabolism
Young Adult
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Summary:The aim of this study was to determine the effect of increasing estrogen and decreasing androgen in males and increasing androgen and decreasing estrogen in females on bone metabolism in patients with gender identity disorder (GID). We measured and examined bone mineral density (BMD) and bone metabolism markers retrospectively in GID patients who were treated in our hospital. In addition, we studied the effects of treatment on those who had osteoporosis. Patients who underwent a change from male to female (MtF) showed inhibition of bone resorption and increased L2–4 BMD whereas those who underwent a change from female to male (FtM) had increased bone resorption and decreased L2–4 BMD. Six months after administration of risedronate to FtM patients with osteoporosis, L2–4 BMD increased and bone resorption markers decreased. These results indicate that estrogen is an important element with regard to bone metabolism in males.
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-011-0342-0