Picomolar level profiling of the methylation status of the p53 tumor suppressor gene by a label-free electrochemical biosensor

An efficient electrochemical approach is developed for ultrasensitive profiling of the methylation status of the p53 tumor suppressor gene based on a label-free biosensor in combination with bisulfite conversion.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (87), p.10754-10756
Main Authors: Wang, Po, Wu, Hai, Dai, Zong, Zou, Xiaoyong
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
DNA Methylation
Electrochemical Techniques
Tumor Suppressor Protein p53 - genetics
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Description
Summary:An efficient electrochemical approach is developed for ultrasensitive profiling of the methylation status of the p53 tumor suppressor gene based on a label-free biosensor in combination with bisulfite conversion.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc35615e