Inhibitory effects of L-pipecolic acid from the edible mushroom, Sarcodon aspratus, on angiotensin I-converting enzyme

The aqueous extract of the edible mushroom Sarcodon aspratus showed inhibitory effects against angiotensin I-converting enzyme (ACE). l -Pipecolic acid ( l -piperidine-2-carboxylic acid) was isolated from a hot-water extract in a 0.02% yield as an active principle. The mode of inhibition of l -pipec...

Full description

Saved in:
Bibliographic Details
Published in:Journal of wood science 2008-04, Vol.54 (2), p.179-181
Main Authors: Kiyoto, M.(Kitami Inst. of Technology, Hokkaido (Japan)), Saito, S, Hattori, K, Cho, N.S, Hara, T, Yagi, Y, Aoyama, M
Format: Article
Language:English
Subjects:
ACIDE ORGANIQUE
ACIDOS ORGANICOS
Acids
ANGIOTENSIN
ANGIOTENSINA
ANGIOTENSINE
Biomedical and Life Sciences
Carboxyl group
CARDIOVASCULAR AGENTS
CHAMPIGNON COMESTIBLE
Characterization and Evaluation of Materials
Conversion
EDIBLE FUNGI
ENZYME INHIBITORS
Enzymes
EXTRACTOS
EXTRACTS
EXTRAIT
HIPERTENSION
HYPERTENSION
INHIBIDORES DE ENZIMAS
INHIBITEUR D'ENZYME
Life Sciences
Materials Science
MEDICAMENTOS CARDIOVASCULARES
MODIFICATEUR CARDIOVASCULAIRE
Mushrooms
ORGANIC ACIDS
Piperidine
SETAS COMESTIBLES
Wood Science & Technology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aqueous extract of the edible mushroom Sarcodon aspratus showed inhibitory effects against angiotensin I-converting enzyme (ACE). l -Pipecolic acid ( l -piperidine-2-carboxylic acid) was isolated from a hot-water extract in a 0.02% yield as an active principle. The mode of inhibition of l -pipecolic acid was found to be competitive, whereas its d -isomer showed no significant inhibitory effects against ACE, suggesting that the configuration of the carboxyl group in the molecule plays an important role in the enzyme inhibition.
ISSN:1435-0211
1611-4663
DOI:10.1007/s10086-007-0923-7