Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India

► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC. The study was undertaken to investigate the clinical implications of...

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Published in:Infection, genetics and evolution genetics and evolution, 2012-12, Vol.12 (8), p.1622-1629
Main Authors: Panigrahi, Rajesh, Biswas, Avik, Banerjee, Arup, Singh, Shivaram Prasad, Panigrahi, Manas K., Roque-Afonso, Anne Marie, Das, Haribhakti Seba, Mahapatra, Pradip K., Chakrabarti, Sekhar, Chakravarty, Runu
Format: Article
Language:English
Subjects:
Adult
Aged
Amino Acid Sequence
BCP mutations
Biological and medical sciences
Carcinoma, Hepatocellular - virology
Chi-Square Distribution
Consensus Sequence
DNA
DNA, Viral - genetics
Epidemiology. Vaccinations
Female
General aspects
genes
Genes, Viral
Genotype
HBV subgenotype D5
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - genetics
hepatoma
Human viral diseases
Humans
Hydrophobic and Hydrophilic Interactions
immunology
India - epidemiology
Infectious diseases
liver
liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - virology
Liver Neoplasms - virology
Male
Medical sciences
MHR mutations
Middle Aged
Molecular Sequence Data
Mutation
Orissa
patients
Phylogeny
polymerase chain reaction
sequence analysis
Viral diseases
Viral hepatitis
Viral Load
Viral Proteins - chemistry
Viral Proteins - genetics
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Summary:► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC. The study was undertaken to investigate the clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP), precore (PC) and surface gene mutations in HBV infected patients from Orissa, southeastern India. HBV infections were identified by serology testing and HBV DNA amplification by polymerase chain reaction among the 152 patients. After sequencing, surface gene mutation were studied by sequence analysis as well as by using BLOSUM scores and BCP mutations were studied only by sequence analysis. A high proportion of HBV/D5 (66.0%) was found among the study samples having significant relation with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients (p
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2012.06.015