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Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India
► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC. The study was undertaken to investigate the clinical implications of...
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| Published in: | Infection, genetics and evolution genetics and evolution, 2012-12, Vol.12 (8), p.1622-1629 |
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| container_title | Infection, genetics and evolution |
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| creator | Panigrahi, Rajesh Biswas, Avik Banerjee, Arup Singh, Shivaram Prasad Panigrahi, Manas K. Roque-Afonso, Anne Marie Das, Haribhakti Seba Mahapatra, Pradip K. Chakrabarti, Sekhar Chakravarty, Runu |
| description | ► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC.
The study was undertaken to investigate the clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP), precore (PC) and surface gene mutations in HBV infected patients from Orissa, southeastern India. HBV infections were identified by serology testing and HBV DNA amplification by polymerase chain reaction among the 152 patients. After sequencing, surface gene mutation were studied by sequence analysis as well as by using BLOSUM scores and BCP mutations were studied only by sequence analysis. A high proportion of HBV/D5 (66.0%) was found among the study samples having significant relation with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients (p |
| doi_str_mv | 10.1016/j.meegid.2012.06.015 |
| format | article |
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The study was undertaken to investigate the clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP), precore (PC) and surface gene mutations in HBV infected patients from Orissa, southeastern India. HBV infections were identified by serology testing and HBV DNA amplification by polymerase chain reaction among the 152 patients. After sequencing, surface gene mutation were studied by sequence analysis as well as by using BLOSUM scores and BCP mutations were studied only by sequence analysis. A high proportion of HBV/D5 (66.0%) was found among the study samples having significant relation with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients (p<0.05). The BCP mutation, TA (81.4%) and C1753/TA (75.0%) was found in significant proportion (p<0.05) among HCC cases and in fact a gradual increase in these mutations were noted between inactive carriers (IC) to HCC group and also showed higher viral load. An increasing trend of major hydrophilic region (MHR) mutations in S gene was also observed from IC (56.0%) to chronic liver disease (CLD) (60.4%) to LC (72.4%) to HCC (95.0%) patients. In conclusion, our study suggests that the predominant HBV subgenotype HBV/D5 with high viral load and BCP mutations (double and triple) and high mutations in MHR region was significantly associated with advanced liver disease (LC and HCC) and might act as predictor of severe hepatic complications.</description><identifier>ISSN: 1567-1348</identifier><identifier>EISSN: 1567-7257</identifier><identifier>DOI: 10.1016/j.meegid.2012.06.015</identifier><identifier>PMID: 22820088</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adult ; Aged ; Amino Acid Sequence ; BCP mutations ; Biological and medical sciences ; Carcinoma, Hepatocellular - virology ; Chi-Square Distribution ; Consensus Sequence ; DNA ; DNA, Viral - genetics ; Epidemiology. Vaccinations ; Female ; General aspects ; genes ; Genes, Viral ; Genotype ; HBV subgenotype D5 ; Hepatitis B - complications ; Hepatitis B - epidemiology ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus - genetics ; hepatoma ; Human viral diseases ; Humans ; Hydrophobic and Hydrophilic Interactions ; immunology ; India - epidemiology ; Infectious diseases ; liver ; liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - virology ; Liver Neoplasms - virology ; Male ; Medical sciences ; MHR mutations ; Middle Aged ; Molecular Sequence Data ; Mutation ; Orissa ; patients ; Phylogeny ; polymerase chain reaction ; sequence analysis ; Viral diseases ; Viral hepatitis ; Viral Load ; Viral Proteins - chemistry ; Viral Proteins - genetics</subject><ispartof>Infection, genetics and evolution, 2012-12, Vol.12 (8), p.1622-1629</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-268df42066df4b91a80a2679573be27de3fdb17faac1672a1a099966cc1b4cad3</citedby><cites>FETCH-LOGICAL-c416t-268df42066df4b91a80a2679573be27de3fdb17faac1672a1a099966cc1b4cad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26617043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22820088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panigrahi, Rajesh</creatorcontrib><creatorcontrib>Biswas, Avik</creatorcontrib><creatorcontrib>Banerjee, Arup</creatorcontrib><creatorcontrib>Singh, Shivaram Prasad</creatorcontrib><creatorcontrib>Panigrahi, Manas K.</creatorcontrib><creatorcontrib>Roque-Afonso, Anne Marie</creatorcontrib><creatorcontrib>Das, Haribhakti Seba</creatorcontrib><creatorcontrib>Mahapatra, Pradip K.</creatorcontrib><creatorcontrib>Chakrabarti, Sekhar</creatorcontrib><creatorcontrib>Chakravarty, Runu</creatorcontrib><title>Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India</title><title>Infection, genetics and evolution</title><addtitle>Infect Genet Evol</addtitle><description>► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC.
The study was undertaken to investigate the clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP), precore (PC) and surface gene mutations in HBV infected patients from Orissa, southeastern India. HBV infections were identified by serology testing and HBV DNA amplification by polymerase chain reaction among the 152 patients. After sequencing, surface gene mutation were studied by sequence analysis as well as by using BLOSUM scores and BCP mutations were studied only by sequence analysis. A high proportion of HBV/D5 (66.0%) was found among the study samples having significant relation with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients (p<0.05). The BCP mutation, TA (81.4%) and C1753/TA (75.0%) was found in significant proportion (p<0.05) among HCC cases and in fact a gradual increase in these mutations were noted between inactive carriers (IC) to HCC group and also showed higher viral load. An increasing trend of major hydrophilic region (MHR) mutations in S gene was also observed from IC (56.0%) to chronic liver disease (CLD) (60.4%) to LC (72.4%) to HCC (95.0%) patients. In conclusion, our study suggests that the predominant HBV subgenotype HBV/D5 with high viral load and BCP mutations (double and triple) and high mutations in MHR region was significantly associated with advanced liver disease (LC and HCC) and might act as predictor of severe hepatic complications.</description><subject>Adult</subject><subject>Aged</subject><subject>Amino Acid Sequence</subject><subject>BCP mutations</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Chi-Square Distribution</subject><subject>Consensus Sequence</subject><subject>DNA</subject><subject>DNA, Viral - genetics</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>General aspects</subject><subject>genes</subject><subject>Genes, Viral</subject><subject>Genotype</subject><subject>HBV subgenotype D5</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>hepatoma</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>immunology</subject><subject>India - epidemiology</subject><subject>Infectious diseases</subject><subject>liver</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver Neoplasms - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MHR mutations</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Orissa</subject><subject>patients</subject><subject>Phylogeny</subject><subject>polymerase chain reaction</subject><subject>sequence analysis</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral Load</subject><subject>Viral Proteins - chemistry</subject><subject>Viral Proteins - genetics</subject><issn>1567-1348</issn><issn>1567-7257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhiMEoh_wDxD4gsShG8ZOYieXSnQLtFJREaVna2I7i1eJHeykUsWfx6sEuCEfxtb7jMd6nGWvKOQUKH-_zwdjdlbnDCjLgedAqyfZMa242AhWiafrnhZlfZSdxLgHoAJY_Tw7YqxmAHV9nP26m9udcX56HA25rM7IxfYrQafJl6tvZJgnnKx3kVhHfpgxHRRRfhh7q9YAB-92azbZSC7Igw3zoaEzajKaHALjpki64AdyG2yMeEaunbb4InvWYR_Ny7WeZvefPn7fXm1ubj9fbz_cbFRJ-bRhvNZdyYDzVNqGYg3IuGgqUbSGCW2KTrdUdIiKcsGQIjRNw7lStC0V6uI0e7fcOwb_czZxkoONyvQ9OuPnKCllVVoF1AktF1QFH2MwnRyDHTA8SgryoF3u5aJdHrRL4DJpT22v1wlzOxj9t-mP5wS8XQGMCvsuoFM2_uM4T19TFol7s3Adeom7ZEve36VJFQCUoqwgEecLYZKxB2uCjCoJVkbbkIxL7e3_3_obQw6rtQ</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Panigrahi, Rajesh</creator><creator>Biswas, Avik</creator><creator>Banerjee, Arup</creator><creator>Singh, Shivaram Prasad</creator><creator>Panigrahi, Manas K.</creator><creator>Roque-Afonso, Anne Marie</creator><creator>Das, Haribhakti Seba</creator><creator>Mahapatra, Pradip K.</creator><creator>Chakrabarti, Sekhar</creator><creator>Chakravarty, Runu</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India</title><author>Panigrahi, Rajesh ; Biswas, Avik ; Banerjee, Arup ; Singh, Shivaram Prasad ; Panigrahi, Manas K. ; Roque-Afonso, Anne Marie ; Das, Haribhakti Seba ; Mahapatra, Pradip K. ; Chakrabarti, Sekhar ; Chakravarty, Runu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-268df42066df4b91a80a2679573be27de3fdb17faac1672a1a099966cc1b4cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amino Acid Sequence</topic><topic>BCP mutations</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Chi-Square Distribution</topic><topic>Consensus Sequence</topic><topic>DNA</topic><topic>DNA, Viral - genetics</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>General aspects</topic><topic>genes</topic><topic>Genes, Viral</topic><topic>Genotype</topic><topic>HBV subgenotype D5</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>hepatoma</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>immunology</topic><topic>India - epidemiology</topic><topic>Infectious diseases</topic><topic>liver</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver Neoplasms - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MHR mutations</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Orissa</topic><topic>patients</topic><topic>Phylogeny</topic><topic>polymerase chain reaction</topic><topic>sequence analysis</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral Load</topic><topic>Viral Proteins - chemistry</topic><topic>Viral Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panigrahi, Rajesh</creatorcontrib><creatorcontrib>Biswas, Avik</creatorcontrib><creatorcontrib>Banerjee, Arup</creatorcontrib><creatorcontrib>Singh, Shivaram Prasad</creatorcontrib><creatorcontrib>Panigrahi, Manas K.</creatorcontrib><creatorcontrib>Roque-Afonso, Anne Marie</creatorcontrib><creatorcontrib>Das, Haribhakti Seba</creatorcontrib><creatorcontrib>Mahapatra, Pradip K.</creatorcontrib><creatorcontrib>Chakrabarti, Sekhar</creatorcontrib><creatorcontrib>Chakravarty, Runu</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Infection, genetics and evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panigrahi, Rajesh</au><au>Biswas, Avik</au><au>Banerjee, Arup</au><au>Singh, Shivaram Prasad</au><au>Panigrahi, Manas K.</au><au>Roque-Afonso, Anne Marie</au><au>Das, Haribhakti Seba</au><au>Mahapatra, Pradip K.</au><au>Chakrabarti, Sekhar</au><au>Chakravarty, Runu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India</atitle><jtitle>Infection, genetics and evolution</jtitle><addtitle>Infect Genet Evol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>12</volume><issue>8</issue><spage>1622</spage><epage>1629</epage><pages>1622-1629</pages><issn>1567-1348</issn><eissn>1567-7257</eissn><abstract>► Unique relation of hepatocellular carcinoma (HCC) with HBV/D5. ► High prevalence of BCP and C1753/T1762/A1764 mutation among HBV/D5 in LC and HCC. ► Increasing S gene mutation observed from inactive carrier to cirrhosis and HCC.
The study was undertaken to investigate the clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP), precore (PC) and surface gene mutations in HBV infected patients from Orissa, southeastern India. HBV infections were identified by serology testing and HBV DNA amplification by polymerase chain reaction among the 152 patients. After sequencing, surface gene mutation were studied by sequence analysis as well as by using BLOSUM scores and BCP mutations were studied only by sequence analysis. A high proportion of HBV/D5 (66.0%) was found among the study samples having significant relation with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients (p<0.05). The BCP mutation, TA (81.4%) and C1753/TA (75.0%) was found in significant proportion (p<0.05) among HCC cases and in fact a gradual increase in these mutations were noted between inactive carriers (IC) to HCC group and also showed higher viral load. An increasing trend of major hydrophilic region (MHR) mutations in S gene was also observed from IC (56.0%) to chronic liver disease (CLD) (60.4%) to LC (72.4%) to HCC (95.0%) patients. In conclusion, our study suggests that the predominant HBV subgenotype HBV/D5 with high viral load and BCP mutations (double and triple) and high mutations in MHR region was significantly associated with advanced liver disease (LC and HCC) and might act as predictor of severe hepatic complications.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22820088</pmid><doi>10.1016/j.meegid.2012.06.015</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Amino Acid Sequence BCP mutations Biological and medical sciences Carcinoma, Hepatocellular - virology Chi-Square Distribution Consensus Sequence DNA DNA, Viral - genetics Epidemiology. Vaccinations Female General aspects genes Genes, Viral Genotype HBV subgenotype D5 Hepatitis B - complications Hepatitis B - epidemiology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics hepatoma Human viral diseases Humans Hydrophobic and Hydrophilic Interactions immunology India - epidemiology Infectious diseases liver liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - virology Liver Neoplasms - virology Male Medical sciences MHR mutations Middle Aged Molecular Sequence Data Mutation Orissa patients Phylogeny polymerase chain reaction sequence analysis Viral diseases Viral hepatitis Viral Load Viral Proteins - chemistry Viral Proteins - genetics |
| title | Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India |
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