Photodynamic and Photothermal Effects of Semiconducting and Metallic-Enriched Single-Walled Carbon Nanotubes

Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H2O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs,...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2012-10, Vol.134 (43), p.17862-17865
Main Authors: Murakami, Tatsuya, Nakatsuji, Hirotaka, Inada, Mami, Matoba, Yoshinori, Umeyama, Tomokazu, Tsujimoto, Masahiko, Isoda, Seiji, Hashida, Mitsuru, Imahori, Hiroshi
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Nanotubes, Carbon - chemistry
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Reactive Oxygen Species - metabolism
Semiconductors
Structure-Activity Relationship
Temperature
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Summary:Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H2O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs, whereas m-SWNTs produced heat more efficiently than s-SWNTs. More importantly, cancer cell killing by PDE of s-SWNTs has been disclosed for the first time.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3079972