Inhibition of TNF-[small alpha] stimulated nuclear factor-kappa B (NF-[small kappa]B) activation by cyclometalated platinum(ii) complexes

Cyclometalated platinum(ii) complexes [PtII(C[logical and]N[logical and]N)(C[triple bond, length as m-dash]NR)]+ (HC[logical and]N[logical and]N = 6-phenyl-2,2[prime or minute]-bipyridyl) display significant inhibition towards TNF-[small alpha] stimulated NF-[small kappa]B-dependent gene transcripti...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (2), p.230-232
Main Authors: Liu, Jia, Sun, Raymond Wai-Yin, Leung, Chung-Hang, Lok, Chun-Nam, Che, Chi-Ming
Format: Article
Language:English
Subjects:
Activation
Bonding
Genes
Inhibition
Online Access:Get full text
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Summary:Cyclometalated platinum(ii) complexes [PtII(C[logical and]N[logical and]N)(C[triple bond, length as m-dash]NR)]+ (HC[logical and]N[logical and]N = 6-phenyl-2,2[prime or minute]-bipyridyl) display significant inhibition towards TNF-[small alpha] stimulated NF-[small kappa]B-dependent gene transcription at concentrations down to the micromolar range.
ISSN:1359-7345
DOI:10.1039/C1CC15317J