Successful Amelioration of Tinnitus in a Stroke Patient by Low-dose Gabapentin

Bilaterally progressive tinnitus and hearing impairment occurred in a hypertensive patient shortly after an episode of right ganglionic hemorrhage. Audiometric tests showed a mixed sensorineural and conduction hearing loss. When low-dose gabapentin was administrated for the pre-existing postherpetic...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2012-11, Vol.21 (8), p.907.e1-907.e4
Main Authors: Chen, Wei-Hsi, MD, MSc, Yin, Hsin-Ling, MD, MSc
Format: Article
Language:English
Subjects:
Amines - administration & dosage
Audiometry, Pure-Tone
Basal Ganglia Hemorrhage - complications
Basal Ganglia Hemorrhage - diagnosis
Cardiovascular
Cerebral Angiography - methods
Cyclohexanecarboxylic Acids - administration & dosage
Excitatory Amino Acid Antagonists - administration & dosage
gabapentin
gamma-Aminobutyric Acid - administration & dosage
ganglion
hearing
Hearing Loss, Mixed Conductive-Sensorineural - diagnosis
Hearing Loss, Mixed Conductive-Sensorineural - etiology
Humans
Male
Middle Aged
Neuralgia, Postherpetic - complications
Neuralgia, Postherpetic - drug therapy
Neurology
stroke
Stroke - complications
Stroke - diagnosis
tinnitus
Tinnitus - diagnosis
Tinnitus - drug therapy
Tinnitus - etiology
Tomography, X-Ray Computed
Treatment Outcome
γ-aminobutyric acid
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Description
Summary:Bilaterally progressive tinnitus and hearing impairment occurred in a hypertensive patient shortly after an episode of right ganglionic hemorrhage. Audiometric tests showed a mixed sensorineural and conduction hearing loss. When low-dose gabapentin was administrated for the pre-existing postherpetic thoracic neuralgia, the tinnitus dramatically improved but recurred after discontinuation of the drug. Hearing function did not change. In view of a controversy of gabapentin and tinnitus in previous trials, the findings in this patient support that low-dose gabapentin benefits the subgroup of tinnitus patients with secondary contributing factors, such as stroke.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2011.07.014