Acute Cerebellar Infarction Associated with Intravenous Gammaglobulin Treatment in Idiopathic Thrombocytopenic Purpura

Intravenous immunoglobulins (IVIGs) are used for a variety of immunologic and hematologic disorders. Hemorheologic alteration or the rapid increase of platelet counts by IVIG administration can cause thrombotic adverse events. We present a 58-year-old woman with a pervious diagnosis of idiopathic th...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2012-11, Vol.21 (8), p.917.e9-917.e11
Main Authors: Choi, Woo-Joo, MD, Kim, Min-Jee, MD, Kim, Chulho, MD, Sohn, Jong Hee, MD, Choi, Hui-Chul, MD, PhD
Format: Article
Language:English
Subjects:
Aspirin - therapeutic use
Brain Infarction - chemically induced
Brain Infarction - diagnosis
Brain Infarction - drug therapy
Cardiovascular
Cerebellum - blood supply
Cerebellum - drug effects
Cerebellum - pathology
Cerebral Angiography - methods
Cerebral infarction
Female
gamma-Globulins - administration & dosage
gamma-Globulins - adverse effects
Humans
idiopathic thrombocytopenic purpura
Immunoglobulins, Intravenous - administration & dosage
Immunoglobulins, Intravenous - adverse effects
Infusions, Intravenous
intravenous immunoglobulins
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Middle Aged
Neurology
Purpura, Thrombocytopenic, Idiopathic - diagnosis
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Time Factors
Treatment Outcome
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Description
Summary:Intravenous immunoglobulins (IVIGs) are used for a variety of immunologic and hematologic disorders. Hemorheologic alteration or the rapid increase of platelet counts by IVIG administration can cause thrombotic adverse events. We present a 58-year-old woman with a pervious diagnosis of idiopathic thrombocytopenic purpura who developed cerebellar infarction immediately after IVIG treatment. We discuss a possible role of IVIG in cerebral ischemia and management strategies.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2012.05.006