Behavioural outcomes of perinatal maternal fluoxetine treatment

Highlights ► Mouse dams were treated with fluoxetine from embryonic day 15 to postnatal day 12. ► A dose of 25 mg/kg/day was administered non-stressfully via drinking water. ► Behavioural outcomes in female offspring were examined in early adulthood. ► Perinatal treatment resulted in decreased anxie...

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Bibliographic Details
Published in:Neuroscience 2012-12, Vol.226, p.356-366
Main Authors: McAllister, B.B, Kiryanova, V, Dyck, R.H
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antidepressive Agents, Second-Generation - pharmacology
anxiety
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Body Weight - drug effects
depression
Fear - psychology
Female
Fluoxetine - pharmacology
Fundamental and applied biological sciences. Psychology
Litter Size
Maze Learning - physiology
Memory - physiology
Memory, Short-Term - physiology
Mice
Mice, Inbred C57BL
Motor Activity - physiology
neurodevelopment
Neurology
Neurotransmission and behavior
Postural Balance - physiology
Pregnancy
Prenatal Exposure Delayed Effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reflex, Startle - physiology
serotonin
Serotonin Uptake Inhibitors - pharmacology
Sex Characteristics
Sex Ratio
SSRI exposure
Swimming - psychology
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Summary:Highlights ► Mouse dams were treated with fluoxetine from embryonic day 15 to postnatal day 12. ► A dose of 25 mg/kg/day was administered non-stressfully via drinking water. ► Behavioural outcomes in female offspring were examined in early adulthood. ► Perinatal treatment resulted in decreased anxiety- and depression-like behaviour. ► Outcomes of perinatal treatment were generally minimal and possibly beneficial.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.09.024