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Behavioural outcomes of perinatal maternal fluoxetine treatment
Highlights ► Mouse dams were treated with fluoxetine from embryonic day 15 to postnatal day 12. ► A dose of 25 mg/kg/day was administered non-stressfully via drinking water. ► Behavioural outcomes in female offspring were examined in early adulthood. ► Perinatal treatment resulted in decreased anxie...
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Published in: | Neuroscience 2012-12, Vol.226, p.356-366 |
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description | Highlights ► Mouse dams were treated with fluoxetine from embryonic day 15 to postnatal day 12. ► A dose of 25 mg/kg/day was administered non-stressfully via drinking water. ► Behavioural outcomes in female offspring were examined in early adulthood. ► Perinatal treatment resulted in decreased anxiety- and depression-like behaviour. ► Outcomes of perinatal treatment were generally minimal and possibly beneficial. |
doi_str_mv | 10.1016/j.neuroscience.2012.09.024 |
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subjects | Animals Animals, Newborn Antidepressive Agents, Second-Generation - pharmacology anxiety Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Body Weight - drug effects depression Fear - psychology Female Fluoxetine - pharmacology Fundamental and applied biological sciences. Psychology Litter Size Maze Learning - physiology Memory - physiology Memory, Short-Term - physiology Mice Mice, Inbred C57BL Motor Activity - physiology neurodevelopment Neurology Neurotransmission and behavior Postural Balance - physiology Pregnancy Prenatal Exposure Delayed Effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reflex, Startle - physiology serotonin Serotonin Uptake Inhibitors - pharmacology Sex Characteristics Sex Ratio SSRI exposure Swimming - psychology |
title | Behavioural outcomes of perinatal maternal fluoxetine treatment |
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