Heparin-induced Thrombocytopenia in Essential Thrombocytosis

We report a 67-year-old woman with essential thrombocytosis who developed cerebral infarction and heparin-induced thrombocytopenia during treatment for the cerebral infarction. She developed additional cerebral infarcts, acute femoral artery occlusion, and thrombophlebitis of her lower extremities....

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2012-11, Vol.21 (8), p.916.e1-916.e5
Main Authors: Murawaki, Ayumi, MD, Nakayasu, Hiroyuki, MD, Doi, Mitsuru, MD, Suzuki-Kinoshita, Kaori, MD, Asai, Yasumasa, MD, Omura, Hiromi, MD, Nakashima, Kenji, MD
Format: Article
Language:English
Subjects:
Aged
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Argatroban
Arterial Occlusive Diseases - diagnosis
Arterial Occlusive Diseases - etiology
Bone Marrow Examination
Cardiovascular
Cerebral Infarction - diagnosis
Cerebral Infarction - drug therapy
Cerebral Infarction - etiology
Constriction, Pathologic
Diagnosis, Differential
disseminated intravascular coagulation
Disseminated Intravascular Coagulation - diagnosis
essential thrombocytosis
Female
Femoral Artery
Heparin - adverse effects
heparin-induced thrombocytopenia
Humans
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Neurology
Pipecolic Acids - therapeutic use
Platelet Aggregation Inhibitors - therapeutic use
Platelet Count
Predictive Value of Tests
Thrombocythemia, Essential - complications
Thrombocythemia, Essential - diagnosis
Thrombocythemia, Essential - therapy
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnosis
Thrombocytopenia - therapy
thromboembolism
Thrombophlebitis - diagnosis
Thrombophlebitis - etiology
Treatment Outcome
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Description
Summary:We report a 67-year-old woman with essential thrombocytosis who developed cerebral infarction and heparin-induced thrombocytopenia during treatment for the cerebral infarction. She developed additional cerebral infarcts, acute femoral artery occlusion, and thrombophlebitis of her lower extremities. She was successfully treated with argatroban. This is the first report of a patient with essential thrombocytosis who developed heparin-induced thrombocytopenia and serious conditions, which included multiple thromboembolisms and coagulation disorders mimicking disseminated intravascular coagulation.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2012.02.011