Exanthematous drug eruption due to valsartan

Objective: Valsartan is an angiotensin II receptor blocker (ARB) used for treatment of hypertension. The well-known adverse effects of valsartan are dizziness, headache and cough. Valsartan-related cutaneous side effects have been reported previously in a limited number of case reports. Materials an...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2012-12, Vol.31 (4), p.335-337
Main Authors: Ozturk, Gunseli, Turk, Bengu Gerceker, Senturk, Bircan, Turkmen, Meltem, Kandiloglu, Gulsen
Format: Article
Language:English
Subjects:
Angiotensin II Type 1 Receptor Blockers - adverse effects
Antihypertensive Agents - adverse effects
Drug Eruptions - etiology
Drug Eruptions - pathology
Erythema - chemically induced
Erythema - pathology
Exanthema - chemically induced
Exanthema - pathology
Humans
Male
Middle Aged
Tetrazoles - adverse effects
Valine - adverse effects
Valine - analogs & derivatives
Valsartan
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Summary:Objective: Valsartan is an angiotensin II receptor blocker (ARB) used for treatment of hypertension. The well-known adverse effects of valsartan are dizziness, headache and cough. Valsartan-related cutaneous side effects have been reported previously in a limited number of case reports. Materials and methods: A 47-year-old man admitted with diffuse, itchy erythematous maculopapular eruption all over the body. He has been taking 160 mg valsartan daily for 10 days before onset of the eruption. On the third day of valsartan therapy, erythema had appeared over the face and spread throughout the whole body within a week. Histopathologic examination of the lesions showed lymphocyte exocytosis, spongiosis, necrotic keratinocytes in the epidermis, and mixed inflammatory cell infiltrates including perivascular eosinophils in the dermis. The patient was diagnosed as drug reaction due to valsartan with historical, clinical and histopathologic features. Discussion and conclusion: Most common antihypertensive agents including diuretics, beta blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors have many cutaneous side effects. However, there are a few reports about the cutaneous side effects of ARBs. Physicians should be aware of the cutaneous side effects of this commonly used agent and valsartan should be considered as a triggering factor of an exanthematous drug reactions.
ISSN:1556-9527
1556-9535
DOI:10.3109/15569527.2011.647179