Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant

• Published in: Diabetes/metabolism research and reviews 2012-11, Vol.28 (8), p.663-668
• Main Authors: de Luis, Daniel Antonio, Aller, Rocío, Izaola, Olatz, de la Fuente, Beatriz, Conde, Rosa, Sagrado, Manuel Gonzalez, Primo, David
• Format: Article
• Language: English
• Subjects: adipocytokines; Adipokines - blood; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cardiovascular Diseases - etiology; Diet, Fat-Restricted; Diet, Reducing; Dietary Carbohydrates - administration & dosage; Female; Humans; Male; Middle Aged; obesity; Obesity - genetics; Polymorphism, Genetic; Prospective Studies; Proteins - genetics; Risk Factors; rs9939609 gene variant; two hypocaloric diet; Weight Loss - genetics
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/dmrr.2323

Background Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. One of these genetic variants (rs9939609) has been related to an increased risk of obesity. Objective Our aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with RS9939609 gene variant. Design 305 obese patients were enrolled in a prospective way. In the basal visit, patients were randomly allocated during 3 months to low carbohydrates and low fat. Results After treatment with both diets and in both genotypes, weight, fat mass, waist circumference and systolic blood pressures decreased. With the diet type I and in TT genotype, insulin (−6.6 ± 9.8 IU/L) and homeostasis model assessment (−2.9 ± 6.1 units) decreased. With the diet type II and in both genotypes (wild and mutant type), insulin (−5.2 ± 6.1 vs. −3.8 ± 6.1 IU/L; p