Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes

• Published in: Diabetes/metabolism research and reviews 2012-11, Vol.28 (8), p.679-687
• Main Authors: Tang, Song-tao, Peng, Wen-jia, Wang, Chang-jiang, Tang, Hai-qin, Zhang, Qiu
• Format: Article
• Language: English
• Subjects: Asian Continental Ancestry Group - genetics; Case-Control Studies; diabetes; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - genetics; European Continental Ancestry Group - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; meta-analysis; polymorphism; Small Ubiquitin-Related Modifier Proteins - genetics; SUMO4
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/dmrr.2335

Background The association between small ubiquitin‐like modifier 4 (SUMO4) gene polymorphism and type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) has been investigated in several studies. We conducted a meta‐analysis to evaluate the association of SUMO4 gene polymorphism with T1DM and T2DM susceptibility. Methods A meta‐analysis was performed on the published studies before August 2011. The association of SUMO4 M55V polymorphism with T1DM and T2DM was evaluated. Meta‐analysis was performed for genotypes AA versus GG, AA versus AG, AA versus AG + GG and A allele versus G allele in a fixed/random effect model. The combined odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of the association. Results Sixteen case–control studies including 9190 cases and 10 456 healthy controls were included. T1DM patients were divided into Asian and Caucasian subgroup. We detected a significant association of SUMO4 M55V polymorphism with T1DM in Asian population (A versus G: OR = 0.79, 95%CI = 0.72–0.86, p = 0.000) and a significant association of SUMO4 M55V polymorphism with T1DM in Caucasian population (A versus G: OR = 0.84, 95%CI = 0.73–0.97, p = 0.007). Included T2DM patients were all Asian. Meanwhile, a significant association of SUMO4 M55V polymorphism with T2DM was also found (A versus G: OR = 0.86, 95%CI = 0.79–0.94, p = 0.001). Conclusions Our study demonstrates significant associations of SUMO4 M55V polymorphism with T1DM in Asian and Caucasian population and with T2DM in Asian population. Copyright © 2012 John Wiley & Sons, Ltd.