Renal function and systolic blood pressure in very-low-birth-weight infants 1–3 years of age

Background Preterm very-low-birth-weight (PT-VLBW) infants are at risk of an elevated systolic blood pressure (SBP) in infancy and adulthood; however, the pathogenesis remains unclear. Altered renal development or function may be associated with increased SBP, but their contribution in PT-VLBW is un...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2012-12, Vol.27 (12), p.2285-2291
Main Authors: Frankfurt, Joshua A., Duncan, Andrea F., Heyne, Roy J., Rosenfeld, Charles R.
Format: Article
Language:English
Subjects:
Adults
Birth weight
Birth weight, Low
Blood pressure
Blood Pressure - physiology
Cardiovascular disease
Cardiovascular diseases
Child, Preschool
Congenital diseases
Cystatin C - analysis
Cystatin C - blood
Development and progression
Diabetes
Female
Gestational age
Glomerular Filtration Rate - physiology
Humans
Hypertension
Infant
Infant, Newborn
Infant, Premature, Diseases
Infant, Very Low Birth Weight - physiology
Kidney - physiopathology
Male
Medicine
Medicine & Public Health
Nephrology
Nutrition
Original Article
Pathogenesis
Patient outcomes
Pediatrics
Premature birth
Risk factors
Urology
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Summary:Background Preterm very-low-birth-weight (PT-VLBW) infants are at risk of an elevated systolic blood pressure (SBP) in infancy and adulthood; however, the pathogenesis remains unclear. Altered renal development or function may be associated with increased SBP, but their contribution in PT-VLBW is unknown. Methods We determined renal function and its relationship to SBP in three groups of PT-VLBW at 1, 2, and 3 years of age, using serum cystatin-C to calculate the estimated glomerular filtration rate (eGFR). Results Cystatin-C levels decreased from 0.84 ± 0.2 (SD) within the 1-year group to 0.70 ± 0.1 mg/l (±SD; P  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-012-2265-y