Expression and Localization of Aquaporins 8 and 9 in Term Placenta With Oligohydramnios

To test the expression and localization of aquaporins 8 (AQP8) and 9 (AQP9) in human term fetal membranes and placenta in both oligohydramnios and normal amniotic fluid volume (AFV) groups and to explore the association between aquaporin expression and oligohydramnios. Real-time polymerase chain rea...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2012-12, Vol.19 (12), p.1276-1284
Main Authors: Jiang, Shan-Shan, Zhu, Xue-Jie, Ding, Sheng-Di, Wang, Jing-Jing, Jiang, Ling-Ling, Jiang, Wen-Xiao, Zhu, Xue-Qiong
Format: Article
Language:English
Subjects:
Adult
Amnion - chemistry
Amnion - metabolism
Amniotic Fluid
Aquaporins - analysis
Aquaporins - genetics
Biological and medical sciences
Chorion - chemistry
Chorion - metabolism
Diseases of mother, fetus and pregnancy
Embryology
Female
Gene Expression
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Oligohydramnios - metabolism
Original Articles
Placenta - chemistry
Placenta - metabolism
Pregnancy
Pregnancy. Fetus. Placenta
Real-Time Polymerase Chain Reaction
Reproductive Medicine
RNA, Messenger - analysis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To test the expression and localization of aquaporins 8 (AQP8) and 9 (AQP9) in human term fetal membranes and placenta in both oligohydramnios and normal amniotic fluid volume (AFV) groups and to explore the association between aquaporin expression and oligohydramnios. Real-time polymerase chain reaction and immunohistochemistry were used to determine AQP8 and AQP9 expression levels and localization in amnion, chorion, and placenta, respectively. In addition, compared with the normal AFV group, the expression levels of both AQP8 and AQP9 in amnion in oligohydramnios group were significantly decreased, while their expressions in placenta were significantly increased. The expression level of AQP9 was also significantly decreased in chorion, while that of AQP8 was unchanged. Both AQP8 and AQP9 may play an important role in water flow both in intramembranous absorption and in placental water transfer. Our study offers the potential therapeutic approach for oligohydramnios.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719112450328