Serum sex steroid hormones and frailty in older American men of the Third National Health and Nutrition Examination Survey (NHANES III)

Objective: To determine whether frailty is associated with circulating total and free testosterone, total and free estradiol, and sex hormone-binding globulin (SHBG) in older men. Methods: With NHANES III data of 461 men aged 60 years and older, we used logistic regression to analyze the association...

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Bibliographic Details
Published in:The aging male 2012-12, Vol.15 (4), p.208-215
Main Authors: Eichholzer, Monika, Barbir, Aline, Basaria, Shehzad, Dobs, Adrian S., Feinleib, Manning, Guallar, Eliseo, Menke, Andy, Nelson, William G., Rifai, Nader, Platz, Elizabeth A., Rohrmann, Sabine
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Confidence Intervals
elderly men
estradiol
Frail Elderly
Frailty
Gonadal Steroid Hormones - blood
Humans
Immunoglobulins
Logistic Models
Male
Mens health
Nutrition Surveys
Odds Ratio
Older people
Sex Hormone-Binding Globulin - analysis
SHBG
Surveys and Questionnaires
Testosterone
United States
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Summary:Objective: To determine whether frailty is associated with circulating total and free testosterone, total and free estradiol, and sex hormone-binding globulin (SHBG) in older men. Methods: With NHANES III data of 461 men aged 60 years and older, we used logistic regression to analyze the associations between serum concentrations of sex steroid hormones, SHBG and frailty. Participants meeting any three or more of the five frailty criteria were classified as "frail", all others were considered as non-frail. Results: 2.5% of men were frail. Men with SHBG ≥66 nmol/L had three times the odds of frailty (OR = 2.97; 95% CI 1.28-6.86) compared to men with SHBG
ISSN:1368-5538
1473-0790
DOI:10.3109/13685538.2012.705366