Cardiac Magnetic Resonance Evaluation of the Impact of Interventricular and Intraventricular Dyssynchrony on Cardiac Ventricular Systolic and Diastolic Function in Patients With Isolated Left Bundle Branch Block

• Published in: The American journal of cardiology 2012-12, Vol.110 (11), p.1651-1656
• Main Authors: Valenti, Valentina, MD, Zia, Mohammad I., MD, Shubayev, Leon, Edelstein, Sophia, Supariwala, Azhar, MD, Uretsky, Seth, MD, Fantozzi, Luigi Maria, MD, Volpe, Massimo, MD, FAHA, FESC, Sciarretta, Sebastiano, MD, Wolff, Steven D., MD, PhD
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Bundle-Branch Block - diagnosis; Bundle-Branch Block - physiopathology; Bundle-Branch Block - therapy; Cardiac dysrhythmias; Cardiac Resynchronization Therapy; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Diastole; Female; Follow-Up Studies; Heart; Heart attacks; Heart failure; Heart Ventricles - physiopathology; Humans; Magnetic Resonance Imaging, Cine; Male; Medical sciences; Middle Aged; Retrospective Studies; Stroke Volume; Systole; Ventricular Function, Left - physiology; Ventricular Remodeling
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2012.07.036

Ventricular dyssynchrony significantly impairs cardiac performance. However, the independent role of interventricular dyssynchrony (interVD) and intraventricular dyssynchrony (intraVD) in the development of abnormalities of systolic and diastolic performance is unclear. Cardiac magnetic resonance imaging was performed in 39 patients with left bundle branch block and 13 healthy patients. Structural and functional parameters of the left ventricle and degrees of interVD and intraVD were measured. We found that interVD was inversely correlated with left ventricular (LV) ejection fraction (r = −0.8, p