Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer

Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of pyrophosphate to form orthophosphate. Pyrophosphate can substitute for ATP under certain circumstances. We previously conducted a proteomic analysis to investigate tumor-specific protein expression in gastric cancer, and PPase was identif...

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Bibliographic Details
Published in:Tumor biology 2012-12, Vol.33 (6), p.1889-1898
Main Authors: Jeong, Sang-Ho, Ko, Gyung Hyuck, Cho, Young Hyun, Lee, Young-Joon, Cho, Bok-Im, Ha, Woo-Song, Choi, Sang-Kyung, Kim, Jae Won, Lee, Chang Won, Heo, Yoon Seok, Shin, Seok Hwan, Yoo, Jiyun, Hong, Soon-Chan
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - enzymology
Adenocarcinoma, Mucinous - mortality
Adenocarcinoma, Mucinous - pathology
Biomarkers
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Blotting, Western
Cancer Research
Case-Control Studies
Cell Movement
Cell Proliferation
Disease Progression
Electrophoresis, Gel, Two-Dimensional
Female
Gastric cancer
Humans
Immunoenzyme Techniques
Inorganic Pyrophosphatase - antagonists & inhibitors
Inorganic Pyrophosphatase - genetics
Inorganic Pyrophosphatase - metabolism
Lymphatic Metastasis
Male
Medical prognosis
Middle Aged
Neoplasm Recurrence, Local - enzymology
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Prognosis
Real-Time Polymerase Chain Reaction
Research Article
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Small Interfering - genetics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Stomach - enzymology
Stomach - pathology
Stomach Neoplasms - enzymology
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival Rate
Tissue Array Analysis
Tumor Cells, Cultured
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Summary:Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of pyrophosphate to form orthophosphate. Pyrophosphate can substitute for ATP under certain circumstances. We previously conducted a proteomic analysis to investigate tumor-specific protein expression in gastric cancer, and PPase was identified as a potential gastric tumor-specific marker; it was therefore selected for further study. Clinicopathological analysis, using proteomic analysis and immunohistochemistry, was used to validate PPase as a prognostic marker in gastric cancers. Proteomic analysis showed that PPase was overexpressed in patients with lymph node (LN) metastases and high tumor node metastasis (TNM) stages ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-012-0449-5