Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing Endothelial Nitric Oxide Synthase in Healthy Normolipidemic Older Adults

Vascular endothelial dysfunction develops with aging, as indicated by impaired endothelium-dependent dilation, and is related to increased cardiovascular disease risk. We hypothesized that short-term treatment with fenofibrate, a lipid-lowering agent with potential pleiotropic effects, would improve...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-12, Vol.60 (6), p.1517-1523
Main Authors: Walker, Ashley E, Kaplon, Rachelle E, Lucking, Sara Marian S, Russell-Nowlan, Molly J, Eckel, Robert H, Seals, Douglas R
Format: Article
Language:English
Subjects:
Aged
Antioxidants - pharmacology
Arterial hypertension. Arterial hypotension
Ascorbic Acid - pharmacology
Biological and medical sciences
Blood and lymphatic vessels
Blood vessels and receptors
Brachial Artery - drug effects
Brachial Artery - physiology
Cardiology. Vascular system
Double-Blind Method
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Female
Fenofibrate - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Hypolipidemic Agents - pharmacology
Male
Medical sciences
Middle Aged
Nitric Oxide Synthase Type III - metabolism
Oxidative Stress - drug effects
Oxidative Stress - physiology
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
Treatment Outcome
Vasodilation - drug effects
Vasodilation - physiology
Vertebrates: cardiovascular system
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Summary:Vascular endothelial dysfunction develops with aging, as indicated by impaired endothelium-dependent dilation, and is related to increased cardiovascular disease risk. We hypothesized that short-term treatment with fenofibrate, a lipid-lowering agent with potential pleiotropic effects, would improve endothelium-dependent dilation in middle-aged and older normolipidemic adults by reducing oxidative stress. Brachial artery flow-mediated dilation, a measure of endothelium-dependent dilation, was assessed in 22 healthy adults aged 50 to 77 years before and after 7 days of fenofibrate (145 mg/d; n=12) or placebo (n=10). Brachial flow-mediated dilation was unchanged with placebo, but improved after 2 and 7 days of fenofibrate (5.1±0.7 versus 2 days6.0±0.7 and 7 days6.4±0.6%δ; both P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.112.203661