ANTINOCICEPTIVE EFFICACY OF BUPRENORPHINE AND HYDROMORPHONE IN RED-EARED SLIDER TURTLES (TRACHEMYS SCRIPTA ELEGANS)

Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known. In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c. equivalent vol...

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Bibliographic Details
Published in:Journal of zoo and wildlife medicine 2012-09, Vol.43 (3), p.662-665
Main Authors: Mans, Christoph, Lahner, Lesanna L, Baker, Bridget B, Johnson, Stephen M, Sladky, Kurt K
Format: Article
Language:English
Subjects:
Agonists
Analgesia
Analgesics
Animals
antinociception
BRIEF COMMUNICATIONS
buprenorphine
Buprenorphine - administration & dosage
Buprenorphine - pharmacology
Cross-Over Studies
Dose-Response Relationship, Drug
Hot Temperature - adverse effects
Human resources
hydromorphone
Hydromorphone - administration & dosage
Hydromorphone - pharmacology
Medication administration
Morphine
Pain - drug therapy
Pain - etiology
Pain - veterinary
Receptors
Rectal administration
red-eared-slider turtle
Reptiles
Subcutaneous injections
Time Factors
Trachemys scripta elegans
Turtles
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Summary:Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known. In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c. equivalent volume) in 11 healthy red-eared slider turtles (Trachemys scripta elegans). Additionally, buprenorphine at 0.1 and 1 mg/kg was compared with saline in six turtles. Hindlimb withdrawal latencies were measured after exposure to a focal, thermal noxious stimulus before and between 3 hr and up to 96 hr after drug administration. Buprenorphine did not significantly increase hindlimb withdrawal latencies at any time point compared with saline. In contrast, hydromorphone administration at 0.5 mg/kg significantly increased hindlimb withdrawal latencies for up to 24 hr. These results show that hydromorphone, but not buprenorphine, provides thermal antinociception in red-eared slider turtles.
ISSN:1042-7260
1937-2825
DOI:10.1638/2011-0260R.1