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Novel formulation and clinical evaluation of nalidixic acid ointment in impetigo
The aim of this work was to formulate and evaluate nalidixic acid for the first time in different topical ointment bases. Among different ointment formulations, hydrocarbon base achieved the lowest release, while water-soluble base achieved the highest release. The presence of both isopropanol as co...
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| Published in: | Journal of drug delivery science and technology 2012, Vol.22 (4), p.347-352 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c372t-e03ecb98db7d1eef5fa22fe38b8fda316ee9c88e544b6d5de9d6da64e2f021113 |
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| cites | cdi_FETCH-LOGICAL-c372t-e03ecb98db7d1eef5fa22fe38b8fda316ee9c88e544b6d5de9d6da64e2f021113 |
| container_end_page | 352 |
| container_issue | 4 |
| container_start_page | 347 |
| container_title | Journal of drug delivery science and technology |
| container_volume | 22 |
| creator | Tous, S.S. El Sayed, A.M. Abd El Mohsen, M.G. Youssef, E.M.K. Agban, M.N. Boushra, M.F. |
| description | The aim of this work was to formulate and evaluate nalidixic acid for the first time in different topical ointment bases. Among different ointment formulations, hydrocarbon base achieved the lowest release, while water-soluble base achieved the highest release. The presence of both isopropanol as cosolvent and nalidixic acid-sodium benzoate solid dispersion in formula (W8) enhanced both the release and the antibacterial activity of nalidixic acid compared to ointment formula (W5) containing neither of them. A stability study was also performed where no significant change in pH or drug content was observed in all stored formulations (W5 and W8). Stability was further checked by thin-layer chromatography (TLC). After clinical application in impetigo, it was found that the presence of isopropanol and nalidixic acid-sodium benzoate solid dispersion in ointment formulation (W8 ) caused a significant reduction in the mean time of healing (only four days) in impetigo patients. |
| doi_str_mv | 10.1016/S1773-2247(12)50058-4 |
| format | article |
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Among different ointment formulations, hydrocarbon base achieved the lowest release, while water-soluble base achieved the highest release. The presence of both isopropanol as cosolvent and nalidixic acid-sodium benzoate solid dispersion in formula (W8) enhanced both the release and the antibacterial activity of nalidixic acid compared to ointment formula (W5) containing neither of them. A stability study was also performed where no significant change in pH or drug content was observed in all stored formulations (W5 and W8). Stability was further checked by thin-layer chromatography (TLC). After clinical application in impetigo, it was found that the presence of isopropanol and nalidixic acid-sodium benzoate solid dispersion in ointment formulation (W8 ) caused a significant reduction in the mean time of healing (only four days) in impetigo patients.</description><identifier>ISSN: 1773-2247</identifier><identifier>DOI: 10.1016/S1773-2247(12)50058-4</identifier><language>eng</language><publisher>Paris: Elsevier B.V</publisher><subject>Antibacterial activity ; Benzoic acid ; Biological and medical sciences ; Drug delivery ; General pharmacology ; Hydrocarbons ; Impetigo ; Medical sciences ; Nalidixic acid ; Ointment ; Ointments ; pH effects ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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Among different ointment formulations, hydrocarbon base achieved the lowest release, while water-soluble base achieved the highest release. The presence of both isopropanol as cosolvent and nalidixic acid-sodium benzoate solid dispersion in formula (W8) enhanced both the release and the antibacterial activity of nalidixic acid compared to ointment formula (W5) containing neither of them. A stability study was also performed where no significant change in pH or drug content was observed in all stored formulations (W5 and W8). Stability was further checked by thin-layer chromatography (TLC). After clinical application in impetigo, it was found that the presence of isopropanol and nalidixic acid-sodium benzoate solid dispersion in ointment formulation (W8 ) caused a significant reduction in the mean time of healing (only four days) in impetigo patients.</description><subject>Antibacterial activity</subject><subject>Benzoic acid</subject><subject>Biological and medical sciences</subject><subject>Drug delivery</subject><subject>General pharmacology</subject><subject>Hydrocarbons</subject><subject>Impetigo</subject><subject>Medical sciences</subject><subject>Nalidixic acid</subject><subject>Ointment</subject><subject>Ointments</subject><subject>pH effects</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Release</topic><topic>Stability</topic><topic>Therapeutic applications</topic><topic>Thin-layer chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tous, S.S.</creatorcontrib><creatorcontrib>El Sayed, A.M.</creatorcontrib><creatorcontrib>Abd El Mohsen, M.G.</creatorcontrib><creatorcontrib>Youssef, E.M.K.</creatorcontrib><creatorcontrib>Agban, M.N.</creatorcontrib><creatorcontrib>Boushra, M.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of drug delivery science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tous, S.S.</au><au>El Sayed, A.M.</au><au>Abd El Mohsen, M.G.</au><au>Youssef, E.M.K.</au><au>Agban, M.N.</au><au>Boushra, M.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel formulation and clinical evaluation of nalidixic acid ointment in impetigo</atitle><jtitle>Journal of drug delivery science and technology</jtitle><date>2012</date><risdate>2012</risdate><volume>22</volume><issue>4</issue><spage>347</spage><epage>352</epage><pages>347-352</pages><issn>1773-2247</issn><abstract>The aim of this work was to formulate and evaluate nalidixic acid for the first time in different topical ointment bases. Among different ointment formulations, hydrocarbon base achieved the lowest release, while water-soluble base achieved the highest release. The presence of both isopropanol as cosolvent and nalidixic acid-sodium benzoate solid dispersion in formula (W8) enhanced both the release and the antibacterial activity of nalidixic acid compared to ointment formula (W5) containing neither of them. A stability study was also performed where no significant change in pH or drug content was observed in all stored formulations (W5 and W8). Stability was further checked by thin-layer chromatography (TLC). After clinical application in impetigo, it was found that the presence of isopropanol and nalidixic acid-sodium benzoate solid dispersion in ointment formulation (W8 ) caused a significant reduction in the mean time of healing (only four days) in impetigo patients.</abstract><cop>Paris</cop><pub>Elsevier B.V</pub><doi>10.1016/S1773-2247(12)50058-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1773-2247 |
| ispartof | Journal of drug delivery science and technology, 2012, Vol.22 (4), p.347-352 |
| issn | 1773-2247 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1171880652 |
| source | Elsevier |
| subjects | Antibacterial activity Benzoic acid Biological and medical sciences Drug delivery General pharmacology Hydrocarbons Impetigo Medical sciences Nalidixic acid Ointment Ointments pH effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Release Stability Therapeutic applications Thin-layer chromatography |
| title | Novel formulation and clinical evaluation of nalidixic acid ointment in impetigo |
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