Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity

Purpose An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested. Methods We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas pe...

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Bibliographic Details
Published in:Sleep & breathing 2012-12, Vol.16 (4), p.1247-1253
Main Authors: Roemmler, J., Gutt, B., Fischer, R., Vay, S., Wiesmeth, A., Bidlingmaier, M., Schopohl, J., Angstwurm, M.
Format: Article
Language:English
Subjects:
Acromegaly - diagnosis
Acromegaly - epidemiology
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Body mass index
Cross-Sectional Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dentistry
Disease
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Fundamental and applied biological sciences. Psychology
Germany
Growth hormones
Humans
Incidence
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Original Article
Otorhinolaryngology
Pediatrics
Pituitary gland
Pneumology/Respiratory System
Polysomnography
Risk Factors
Sleep apnea
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - epidemiology
Sleep. Vigilance
Statistics as Topic
Vertebrates: nervous system and sense organs
Young Adult
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Summary:Purpose An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested. Methods We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour (respiratory disturbance index = RDI). The type of SA was divided into obstructive (OSA), central (CSA) or mixed (OSA+CSA). Seventeen patients had newly diagnosed disease, and 18 patients were treated with somatostatin analogues. Results Twenty-three patients had controlled disease activity (mean GH levels
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-011-0641-7