Visfatin and its role in obesity development

Abstract Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamid...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2012-04, Vol.6 (2), p.120-124
Main Authors: Stastny, Jiri, Bienertova-Vasku, Julie, Vasku, Anna
Format: Article
Language:English
Subjects:
Adipocytokines
Adipose Tissue - metabolism
Cytokines - metabolism
Endocrinology & Metabolism
Female
Humans
Inflammation - metabolism
Insulin Resistance
Insulin-Secreting Cells - metabolism
Lipid metabolism
Lipids - blood
Male
NAMPT
Nicotinamide Phosphoribosyltransferase - metabolism
Nicotinamide Phosphoribosyltransferase - pharmacology
Obesity
Obesity - metabolism
Visfatin
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Summary:Abstract Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2012.08.011