Synthesis and Bioactive Studies of Complex 8-Hydroxyquinolinato-Bis-(Salicylato) Yttrium (III)

This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power–time curves of the compounds HSA...

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Bibliographic Details
Published in:Biological trace element research 2012-06, Vol.147 (1-3), p.366-373
Main Authors: Li, Xu, Li, Qiang-Guo, Zhang, Hui, Hu, Ji-Lin, Yao, Fei-Hong, Yang, De-Jun, Xiao, Sheng-Xiong, Ye, Li-Juan, Huang, Yi, Guo, Dong-Cai
Format: Article
Language:English
Subjects:
Algorithms
bioactive properties
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Biotechnology
Dose-Response Relationship, Drug
Inhibitory Concentration 50
Life Sciences
metabolism
microbial growth
Microbiology
Models, Biological
Molecular Structure
Nutrition
Oncology
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Quinolinic Acid - chemistry
Salicylates - chemistry
Schizosaccharomyces - drug effects
Schizosaccharomyces - growth & development
Schizosaccharomyces pombe
Spectrophotometry, Infrared
Thermodynamics
Thermogravimetry
Trace elements
X-Ray Diffraction
Yeast
Yttrium
Yttrium - chemistry
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Summary:This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power–time curves of the compounds HSAY, C7H6O3, C9H7NO, and YCl3·6H2O on the growth metabolism of Schizosaccharomyces pombe (S. pombe) were determined at 32.00°C, respectively. The corresponding thermokinetics parameters, which include the microbial growth rate constant (κ), inhibition ratio (I), and half inhibition concentration (IC50), were also derived. The results showed that the generation time was 168.2 min, and all the compounds HSAY, C7H6O3, C9H7NO, and YCl3·6H2O possessed good bioactivities on the growth metabolism of S. pombe, with the values of IC50 being 0.055, 3.57, 0.057, and 1.35 mmol L−1, respectively. The inhibition ability of these compounds above on the growth of the S. pombe has been observed to decrease in the order HSAY>C9H7NO>YCl3·6H2O>C7H6O3.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-011-9297-1