Genetic Polymorphisms Influence Recovery from Traumatic Brain Injury

Traumatic brain injury (TBI) is a major public health concern in both civilian and military populations. Recently, genetics studies have begun to identify individual differences in polymorphisms that could affect recovery and outcome of cognitive and social processes following TBI. This review consi...

Full description

Saved in:
Bibliographic Details
Published in:The Neuroscientist (Baltimore, Md.) Md.), 2012-12, Vol.18 (6), p.631-644
Main Authors: Weaver, Starla M., Chau, Aileen, Portelli, Jaclyn N., Grafman, Jordan
Format: Article
Language:English
Subjects:
Aggression
Animals
Brain Injuries - complications
Brain Injuries - genetics
Brain Injuries - physiopathology
Cognition Disorders - etiology
Cognition Disorders - genetics
Cognitive ability
Decision making
Emotions
Executive function
Gene polymorphism
Humans
impulsive behavior
Polymorphism, Genetic - genetics
Public health
Recovery of Function - genetics
Reviews
Short term memory
Traumatic brain injury
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Traumatic brain injury (TBI) is a major public health concern in both civilian and military populations. Recently, genetics studies have begun to identify individual differences in polymorphisms that could affect recovery and outcome of cognitive and social processes following TBI. This review considers the potential for polymorphisms to influence six specific cognitive and social functions, which represent the most prominent domains of impairment following TBI: working memory, executive function, decision making, inhibition and impulsivity, aggression, and social and emotional function. Examining the influence of polymorphisms on TBI outcome has the potential to contribute to an understanding of variations in TBI outcome, aid in the triaging and treatment of TBI patients, and ultimately lead to targeted interventions based on genetic profiles.
ISSN:1073-8584
1089-4098
DOI:10.1177/1073858411435706