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Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit Th1 polarization
► ADSC could downregulate costimulatory molecules and cytokine secretion of allogenetic DC. ► Treated DC could inhibit CD4+ T cell activation and naïve T cells toward Th1 polarization. ► ADSC could negatively modulate immunity and induce immune tolerance. Adipose tissue-derived stem cells (ADSC) hav...
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Published in: | Cellular immunology 2012-07, Vol.278 (1-2), p.152-157 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | ► ADSC could downregulate costimulatory molecules and cytokine secretion of allogenetic DC. ► Treated DC could inhibit CD4+ T cell activation and naïve T cells toward Th1 polarization. ► ADSC could negatively modulate immunity and induce immune tolerance.
Adipose tissue-derived stem cells (ADSC) have been shown to possess stem cell properties such as transdifferentiation, self-renewal and therapeutic potential. However, the property of ADSC to accommodate immune system is still unknown. In this study, ADSC were cocultured with allogenetic dendritic cells (DC), and then treated DC were mixed with allogenetic CD4+ T cells. The results demonstrated that ADSC could downregulate costimulatory molecules, including CD80, CD83, CD86, and cytokine secretion such as interleukin (IL)-12 and tumor necrosis factor (TNF)-α, while upregulate indoleamine-2,3-dioxygenase (IDO) of allogenetic DC. In addition, treated DC could inhibit CD4+ Tcell activation and naïve T cells toward Th1 polarization.
The results suggest that ADSC could negatively modulate immunity and induce immune tolerance, which provide a promising strategy in transplantation or autoimmune disease. |
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ISSN: | 0008-8749 1090-2163 |
DOI: | 10.1016/j.cellimm.2012.07.008 |