Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery

• Published in: Journal of cranio-maxillo-facial surgery 2012-12, Vol.40 (8), p.e346-e349
• Main Authors: da Costa Araújo, Fábio Andrey, de Santana Santos, Thiago, de Morais, Hécio Henrique Araújo, Laureano Filho, José Rodrigues, de Oliveira e Silva, Emanuel Dias, Vasconcellos, Ricardo José Holanda
• Format: Article
• Language: English
• Subjects: Acetaminophen - therapeutic use; Administration, Oral; Adolescent; Adult; Analgesia; Analgesics, Non-Narcotic - therapeutic use; Analgesics, Opioid - adverse effects; Analgesics, Opioid - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Dentistry; Female; Follow-Up Studies; Humans; Male; Mandible - surgery; Molar, Third - surgery; Oral surgery; Pain; Pain Measurement; Pain, Postoperative - prevention & control; Premedication; Prospective Studies; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Surgery; Third molar; Time Factors; Tooth Extraction; Tooth, Impacted - surgery; Tramadol - adverse effects; Tramadol - therapeutic use; Young Adult
• ISSN: 1010-5182; 1878-4119
• DOI: 10.1016/j.jcms.2012.01.018

Abstract The aim of this prospective, randomized, controlled, paired trial was to perform a comparative analysis of the preemptive analgesic effect of nimesulide and tramadol chlorhydrate during third molar surgery. The study was carried out between March and November 2009, involving 94 operations in 47 male and female patients with bilateral impacted lower third molars in comparable positions. The sample was divided into two groups. Group A received an oral dose of 100 mg of nimesulide 1 h prior to surgery. Group B received an oral dose of 100 mg of tramadol chlorhydrate 1 h prior to surgery. The following aspects were evaluated in the postoperative period: adverse effects of the drugs; amount of rescue medication used (acetaminophen 750 mg); and pain 5, 6, 24, 36, 48, 60, 72 and 84 h after surgery using a visual analog pain scale. Peak pain occurred 5 h after surgery in both groups, with a mean pain score of 2.3 in Group A and 3.0 in Group B; this difference did not achieve statistical significance ( p  > 0.141). Based on the sample studied, nimesulide and tramadol chlorhydrate demonstrate similar preemptive analgesic effects when used in lower third molar surgeries.