Poor efficacy of oral tacrolimus in the treatment of severe generalized atopic eczema in adults: A small retrospective case series

ABSTRACT We report a small, but novel case series of four adults with severe generalized atopic eczema (AE) not responsive to several other immunomodulatory therapies, who were treated with oral tacrolimus (5 mg twice‐daily). Three of the four patients failed therapy with systemic tacrolimus, despit...

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Bibliographic Details
Published in:Australasian journal of dermatology 2012-11, Vol.53 (4), p.295-297
Main Authors: Lee, Frederick J, Frankum, Brad S, Katelaris, Constance H
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
atopic eczema
Biological and medical sciences
calcineurin inhibitors
cyclosporine
Dermatitis, Atopic - drug therapy
Dermatology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
immunosuppression
Immunosuppressive Agents - therapeutic use
Medical sciences
Middle Aged
Retrospective Studies
Skin allergic diseases. Stinging insect allergies
tacrolimus
Tacrolimus - therapeutic use
Tissue, organ and graft immunology
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Summary:ABSTRACT We report a small, but novel case series of four adults with severe generalized atopic eczema (AE) not responsive to several other immunomodulatory therapies, who were treated with oral tacrolimus (5 mg twice‐daily). Three of the four patients failed therapy with systemic tacrolimus, despite two of these showing an initial clinical response; the fourth patient remains on tacrolimus monotherapy with good control of skin disease. Although oral tacrolimus was well‐tolerated in this small group of adults, the clinical efficacy in this series for severe AE was poor. Tacrolimus may yet have a role in less severe disease, but larger prospective studies are required to qualify its place as a treatment option in AE.
ISSN:0004-8380
1440-0960
DOI:10.1111/j.1440-0960.2011.00789.x