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A Neuropsychiatric Perspective of Phenylketonuria I: Overview of Phenylketonuria and Its Neuropsychiatric Sequelae
Phenylketonuria (PKU) is an autosomal recessive metabolic genetic disorder that is associated with neuropsychiatric sequelae of varying severity. The natural history, epidemiology, and a history of the medical understanding and approaches to treatment of PKU are presented. Neurocognitive and neurops...
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| Published in: | Psychosomatics (Washington, D.C.) D.C.), 2012-11, Vol.53 (6), p.517-523 |
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| cites | cdi_FETCH-LOGICAL-c485t-f6e3c731fbcf48edd9897957450476ef4a1c1f8a8a72afce6005e43bc24cfa2e3 |
| container_end_page | 523 |
| container_issue | 6 |
| container_start_page | 517 |
| container_title | Psychosomatics (Washington, D.C.) |
| container_volume | 53 |
| creator | Bone, Ashley, M.D Kuehl, Angela K., Pharm.D., M.S Angelino, Andrew F., M.D., D.F.A.P.A |
| description | Phenylketonuria (PKU) is an autosomal recessive metabolic genetic disorder that is associated with neuropsychiatric sequelae of varying severity. The natural history, epidemiology, and a history of the medical understanding and approaches to treatment of PKU are presented. Neurocognitive and neuropsychiatric sequelae of patients with untreated, early-treated, and continuously-treated PKU are described, and possible mechanisms for the symptoms are proposed. The authors propose an integrated approach to management of patients with PKU. |
| doi_str_mv | 10.1016/j.psym.2012.04.010 |
| format | article |
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| identifier | ISSN: 0033-3182 |
| ispartof | Psychosomatics (Washington, D.C.), 2012-11, Vol.53 (6), p.517-523 |
| issn | 0033-3182 1545-7206 |
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| source | ScienceDirect Freedom Collection |
| subjects | Age Factors Aminoacid disorders Biological and medical sciences Brain - metabolism Brain - physiopathology Child Child Behavior Disorders - etiology Cognition Disorders - blood Cognition Disorders - etiology Cognition Disorders - psychology Developmental Disabilities - blood Developmental Disabilities - etiology Diet, Protein-Restricted Errors of metabolism Humans Internal Medicine Medical sciences Metabolic diseases Neuropsychiatry Patient Compliance Phenylalanine - blood Phenylketonurias - blood Phenylketonurias - complications Phenylketonurias - therapy Psychiatry Referral and Consultation |
| title | A Neuropsychiatric Perspective of Phenylketonuria I: Overview of Phenylketonuria and Its Neuropsychiatric Sequelae |
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