Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: an individual patient data meta-analysis(†): Meta-Analysis Global Group in Chronic heart failure (MAGGIC)

Hyponatraemia has been associated with reduced survival in patients with heart failure and reduced ejection fraction (HF-REF). The relationship between serum sodium and outcome is unclear in heart failure with preserved (≥ 50%) ejection fraction (HF-PEF). Therefore, we used a large individual patien...

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Bibliographic Details
Published in:European journal of heart failure 2012-10, Vol.14 (10), p.1139-1146
Main Authors: Rusinaru, Dan, Tribouilloy, Christophe, Berry, Colin, Richards, A Mark, Whalley, Gillian A, Earle, Nikki, Poppe, Katrina K, Guazzi, Marco, Macin, Stella M, Komajda, Michel, Doughty, Robert N
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Female
Heart Failure - blood
Heart Failure - complications
Heart Failure - mortality
Humans
Hyponatremia - complications
Hyponatremia - mortality
Male
Middle Aged
Prognosis
Proportional Hazards Models
Risk Factors
Sodium - blood
Stroke Volume
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Summary:Hyponatraemia has been associated with reduced survival in patients with heart failure and reduced ejection fraction (HF-REF). The relationship between serum sodium and outcome is unclear in heart failure with preserved (≥ 50%) ejection fraction (HF-PEF). Therefore, we used a large individual patient data meta-analysis to study the risk of death associated with hyponatraemia in HF-REF and in HF-PEF. This analysis included 14 766 patients from 22 studies that recruited patients without ejection fraction inclusion criterion at baseline and reported death from any cause. Cox proportional analysis was undertaken for hyponatraemia (sodium
ISSN:1388-9842
1879-0844
DOI:10.1093/eurjhf/hfs099