The role of oxidative stress in postprandial endothelial dysfunction

Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that...

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Bibliographic Details
Published in:Nutrition research reviews 2012-12, Vol.25 (2), p.288-301
Main Authors: Lacroix, Sébastien, Rosiers, Christine Des, Tardif, Jean-Claude, Nigam, Anil
Format: Article
Language:English
Subjects:
Atherosclerosis
Biological and medical sciences
Carbohydrates
Cardiovascular disease
Diet, High-Fat - adverse effects
Dietary Carbohydrates - administration & dosage
Dietary Carbohydrates - adverse effects
Endothelium, Vascular - physiopathology
Fatty Acids - administration & dosage
Fatty Acids, Monounsaturated - administration & dosage
Fatty Acids, Unsaturated - administration & dosage
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glucose Tolerance Test
Humans
Hyperglycemia - etiology
Hyperglycemia - physiopathology
Hypertriglyceridemia - etiology
Hypertriglyceridemia - physiopathology
Ingestion
Lipid Peroxidation
Nutrition research
Oils & fats
Oxidative stress
Oxidative Stress - physiology
Trans Fatty Acids - administration & dosage
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that may lead to a transient impairment in endothelial function. The present review will discuss human studies evaluating the impact of high-carbohydrate and high-fat challenges on postprandial endothelial function as well as the potential role of oxidative stress in such postprandial metabolic alterations. Moreover, the present review will differentiate the postprandial endothelial and oxidative impact of meals rich in varying fatty acid types.
ISSN:0954-4224
1475-2700
DOI:10.1017/S0954422412000182