Renal Choriocarcinoma: Gestational or Germ Cell Origin?

Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Di...

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Bibliographic Details
Published in:International journal of surgical pathology 2012-12, Vol.20 (6), p.623-628
Main Authors: Vereczkey, Ildikó, Csernák, Erzsébet, Olasz, Judit, Küronya, Zsófia, Szentirmay, Zoltán, Tóth, Erika
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Choriocarcinoma - drug therapy
Choriocarcinoma - genetics
Choriocarcinoma - secondary
Chorionic Gonadotropin, beta Subunit, Human - blood
Chromosomes, Human, Y - genetics
Combined Modality Therapy
Diagnosis, Differential
DNA, Neoplasm - analysis
Female
Genotype
Germ Cells - pathology
Humans
Kidney Neoplasms - drug therapy
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Lung Neoplasms - secondary
Nephrectomy
Polymorphism, Genetic
Pregnancy
Pregnancy Complications, Neoplastic
Remission Induction
Treatment Outcome
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Summary:Choriocarcinoma is a rare, highly malignant trophoblastic tumor with gestational or, rarely, germ cell origin. Primary extragenital localization is extremely rare. This report describes a choriocarcinoma case clinically mimicking a primary renal cell carcinoma with multiplex pulmonary metastases. Differentiation from a sarcomatoid renal cell carcinoma with trophoblastic differentiation and identification of the exact origin, namely gestational or germ cell origin by molecular genetic methods is of great importance as it helps determine the prognosis and the most effective therapy of the disease. The Investigator Hexaplex ESS Kit was used for DNA polymorphism studies. This showed foreign alleles in the tumor DNA that confirmed the presence of paternal DNA and the gestational origin of the tumor.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896912444160