Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway

Highlights ► Naringin alleviates 3-NP-induced oxidative stress and inflammation. ► Naringin induces Nrf2 activation in 3-NP-induced neurodegeneration. ► Naringin augments the phase II/antioxidant genes through the involvement of Nrf2. ► Naringin decreased the expressions of TNF-α, COX-2 and iNOS....

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Bibliographic Details
Published in:Neuroscience 2012-12, Vol.227, p.134-143
Main Authors: Gopinath, K, Sudhandiran, G
Format: Article
Language:English
Subjects:
3-nitropropionic acid
Administration, Oral
Adult and adolescent clinical studies
Analysis of Variance
Animals
Biological and medical sciences
Convulsants - toxicity
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Corpus Striatum - ultrastructure
Cyclooxygenase 2 - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Down-Regulation - drug effects
Encephalitis - etiology
Encephalitis - prevention & control
Flavanones - administration & dosage
Glutathione - metabolism
Glutathione Disulfide - metabolism
Hydrogen Peroxide - metabolism
Hydroxyl Radical - metabolism
inflammation
Male
Medical sciences
Microscopy, Electron, Transmission
NAD(P)H Dehydrogenase (Quinone) - metabolism
naringin
Neurodegenerative Diseases - chemically induced
Neurodegenerative Diseases - complications
Neurology
Neuroprotective Agents - administration & dosage
NF-E2-Related Factor 2 - metabolism
Nitric Oxide Synthase Type II - genetics
Nitric Oxide Synthase Type II - metabolism
Nitro Compounds - toxicity
nuclear factor-erythroid 2-related factor-2
Organic mental disorders. Neuropsychology
oxidative stress
Oxidative Stress - drug effects
Propionates - toxicity
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Wistar
RNA, Messenger - metabolism
Signal Transduction - drug effects
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
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Summary:Highlights ► Naringin alleviates 3-NP-induced oxidative stress and inflammation. ► Naringin induces Nrf2 activation in 3-NP-induced neurodegeneration. ► Naringin augments the phase II/antioxidant genes through the involvement of Nrf2. ► Naringin decreased the expressions of TNF-α, COX-2 and iNOS.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.07.060