Cytogenetic analysis of gingival epithelial cells, as related to smoking habits and occurrence of periodontal disease

Periodontal disease, progressing from gingivitis to periodontitis, affects the majority of the world population. Its pathogenesis is related to a complex interaction between environmental, microbial, genetic and other host factors, tobacco smoking being the most important environmental risk factor....

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Bibliographic Details
Published in:International journal of hygiene and environmental health 2013-01, Vol.216 (1), p.71-75
Main Authors: D’Agostini, Francesco, Calcagno, Enrico, Micale, Rosanna T., La Maestra, Sebastiano, De Flora, Silvio, Cingano, Luciano
Format: Article
Language:English
Subjects:
Adult
Aged
Air. Soil. Water. Waste. Feeding
Biological and medical sciences
Cigarette smoke
Cytogenetic Analysis
Environment. Living conditions
Epithelial Cells - pathology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gingiva - pathology
Gingival epithelial cells
Humans
Male
Medical sciences
Micronuclei, Chromosome-Defective - statistics & numerical data
Micronucleus test
Middle Aged
Otorhinolaryngology. Stomatology
Periodontal disease
Periodontal Diseases - etiology
Periodontal Diseases - pathology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Smoking - adverse effects
Tobacco, tobacco smoking
Toxicology
Young Adult
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Summary:Periodontal disease, progressing from gingivitis to periodontitis, affects the majority of the world population. Its pathogenesis is related to a complex interaction between environmental, microbial, genetic and other host factors, tobacco smoking being the most important environmental risk factor. Conflicting results are reported in the literature regarding the effects of smoking habits on cytogenetic damage in exfoliated oral cells. We report herein the results of a study evaluating, for the first time, the frequency of micronucleated and binucleated cells in the gingival epithelium. There was no significant elevation of these cytogenetic end-points in 43 subjects as related to smoking habits (never-smokers, ex-smokers, and current smokers) and periodontal disease (mild, moderate, or severe forms of gingivitis and periodontitis). Therefore, the overall data emerging from the present study do not support the evidence for an association between smoking habits, periodontal disease and genotoxic damage in gingival epithelial cells.
ISSN:1438-4639
1618-131X
DOI:10.1016/j.ijheh.2012.01.005