Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma

• Published in: Endocrine pathology 2012-12, Vol.23 (4), p.247-253
• Main Authors: Liu, Zhen, Sun, Da-Xin, Teng, Xu-Yong, Xu, Wei-Xue, Meng, Xiang-Peng, Wang, Bao-Sheng
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers, Tumor - metabolism; Carcinoma - metabolism; Carcinoma - pathology; Carcinoma, Papillary; Chemokine CXCL12 - metabolism; Disease Progression; Endocrinology; Female; Humans; Immunohistochemistry; Lymph Nodes - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Pathology; Receptors, CXCR - metabolism; Thyroid Cancer, Papillary; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology
• ISSN: 1046-3976; 1559-0097
• DOI: 10.1007/s12022-012-9223-x

s Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. SDF-1 and CXCR7 expressions were related with the lymph nodes metastasis of PTC.