Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma

s Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an import...

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Published in:Endocrine pathology 2012-12, Vol.23 (4), p.247-253
Main Authors: Liu, Zhen, Sun, Da-Xin, Teng, Xu-Yong, Xu, Wei-Xue, Meng, Xiang-Peng, Wang, Bao-Sheng
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - metabolism
Carcinoma - metabolism
Carcinoma - pathology
Carcinoma, Papillary
Chemokine CXCL12 - metabolism
Disease Progression
Endocrinology
Female
Humans
Immunohistochemistry
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Pathology
Receptors, CXCR - metabolism
Thyroid Cancer, Papillary
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
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cited_by cdi_FETCH-LOGICAL-c471t-31026080f70e6e6386800d26212538978be054e989b100dc25528c81e08ec12a3
cites cdi_FETCH-LOGICAL-c471t-31026080f70e6e6386800d26212538978be054e989b100dc25528c81e08ec12a3
container_end_page 253
container_issue 4
container_start_page 247
container_title Endocrine pathology
container_volume 23
creator Liu, Zhen
Sun, Da-Xin
Teng, Xu-Yong
Xu, Wei-Xue
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Wang, Bao-Sheng
description s Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. SDF-1 and CXCR7 expressions were related with the lymph nodes metastasis of PTC.
doi_str_mv 10.1007/s12022-012-9223-x
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CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. SDF-1 and CXCR7 expressions were related with the lymph nodes metastasis of PTC.</description><identifier>ISSN: 1046-3976</identifier><identifier>EISSN: 1559-0097</identifier><identifier>DOI: 10.1007/s12022-012-9223-x</identifier><identifier>PMID: 23070788</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biomarkers, Tumor - metabolism ; Carcinoma - metabolism ; Carcinoma - pathology ; Carcinoma, Papillary ; Chemokine CXCL12 - metabolism ; Disease Progression ; Endocrinology ; Female ; Humans ; Immunohistochemistry ; Lymph Nodes - pathology ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Oncology ; Pathology ; Receptors, CXCR - metabolism ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology</subject><ispartof>Endocrine pathology, 2012-12, Vol.23 (4), p.247-253</ispartof><rights>Springer Science+Business Media New York 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-31026080f70e6e6386800d26212538978be054e989b100dc25528c81e08ec12a3</citedby><cites>FETCH-LOGICAL-c471t-31026080f70e6e6386800d26212538978be054e989b100dc25528c81e08ec12a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23070788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhen</creatorcontrib><creatorcontrib>Sun, Da-Xin</creatorcontrib><creatorcontrib>Teng, Xu-Yong</creatorcontrib><creatorcontrib>Xu, Wei-Xue</creatorcontrib><creatorcontrib>Meng, Xiang-Peng</creatorcontrib><creatorcontrib>Wang, Bao-Sheng</creatorcontrib><title>Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma</title><title>Endocrine pathology</title><addtitle>Endocr Pathol</addtitle><addtitle>Endocr Pathol</addtitle><description>s Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. 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CXCR7, a novel receptor for SDF-1, has been identified recently. Researches demonstrated that interaction between SDF-1 and CXCR7 could play an important role in cancer progression. In this study, we aimed to investigate the expressions of SDF-1 and CXCR7 and the relationship between their expressions and clinicopathological characteristics in papillary thyroid carcinoma (PTC). Expressions of SDF-1 and CXCR7 in 33 cases of thyroid benign lesion tissue and 79 cases of PTC tissue and peritumoral non-malignant tissue were detected by immunohistochemical staining. Expressions of SDF-1 and CXCR7 were negative in peritumoral non-malignant tissues. Respectively, positive expression rates of SDF-1 and CXCR7 were 69.6 and 65.8 % in PTC, 12.1 and 30.3 % in thyroid benign tissue. The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis. 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identifier ISSN: 1046-3976
ispartof Endocrine pathology, 2012-12, Vol.23 (4), p.247-253
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source Springer Nature
subjects Adult
Biomarkers, Tumor - metabolism
Carcinoma - metabolism
Carcinoma - pathology
Carcinoma, Papillary
Chemokine CXCL12 - metabolism
Disease Progression
Endocrinology
Female
Humans
Immunohistochemistry
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Pathology
Receptors, CXCR - metabolism
Thyroid Cancer, Papillary
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
title Expression of Stromal Cell-Derived Factor 1 and CXCR7 in Papillary Thyroid Carcinoma
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