Serum levels of BMP-2, 4, 7 and AHSG in patients with degenerative joint disease requiring total arthroplasty of the hip and temporomandibular joints

To date, there is no objective or reliable means of assessing the severity of degenerative joint disease (DJD) and need for joint replacement surgery. Hence, it is difficult to know when an individual with DJD has reached a point where total arthroplasty is indicated. The purpose of the present stud...

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Bibliographic Details
Published in:Journal of orthopaedic research 2013-01, Vol.31 (1), p.44-52
Main Authors: Albilia, Jonathan B., Tenenbaum, Howard C., Clokie, Cameron M. L., Walt, David R., Baker, Gerald I., Psutka, David J., Backstein, David, Peel, Sean A. F.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
AHSG/Fetuin
alpha-2-HS-Glycoprotein - metabolism
arthritis
Arthroplasty, Replacement
Arthroplasty, Replacement, Hip
Biomarkers - blood
BMP
Bone Morphogenetic Protein 2 - blood
Bone Morphogenetic Protein 4 - blood
Bone Morphogenetic Protein 7 - blood
Bone Morphogenetic Proteins - blood
Female
hip
Humans
Male
Middle Aged
Osteoarthritis, Hip - blood
Osteoarthritis, Hip - diagnosis
Osteoarthritis, Hip - surgery
Predictive Value of Tests
Preoperative Care - methods
Severity of Illness Index
Temporomandibular Joint Disorders - blood
Temporomandibular Joint Disorders - diagnosis
Temporomandibular Joint Disorders - surgery
TMJ
Young Adult
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Summary:To date, there is no objective or reliable means of assessing the severity of degenerative joint disease (DJD) and need for joint replacement surgery. Hence, it is difficult to know when an individual with DJD has reached a point where total arthroplasty is indicated. The purpose of the present study is to determine whether serum levels of Alpha‐2 HS‐glycoprotein (AHSG) as well as bone morphogenetic proteins (BMP‐2, 4, 7) can be used to predict the presence of severe DJD of the hip and/or temporomandibular joint (TMJ) (specifically: joints that require replacement). A total of 30 patients scheduled for arthroplasty (diseased) (15 HIP, 15 TMJ) and 120 age‐matched controls (healthy/non‐diseased) were included. Blood samples were collected from all patients ≥8 weeks after the last arthroplasty. Concentrations of serum analytes were measured using enzyme‐linked immunosorbent assays, and these were compared between the Diseased and Healthy groups, utilizing the Mann–Whitney U‐test. Patients with disease had significantly higher levels of BMP‐2 and BMP‐4 and lower levels of AHSG in serum compared to non‐diseased humans (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.22182