The non-casual relation between eosinophilia and thrombotic microangiopathy

Abstract There are only a few cases in the literature that describe s the association between hypereosinophilic syndromes and thrombotic microangiopathy (TMA). Here we present the case of a man who suddenly developed a TMA in the context of eosinophilic pneumonia, who recovered successfully with six...

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Bibliographic Details
Published in:Transfusion and apheresis science 2012-12, Vol.47 (3), p.365-367
Main Authors: Yuste, C, Quiroga, B, Verde, E, Barraca, D, Reque, J.E, Perez de Jose, A, Luño, J
Format: Article
Language:English
Subjects:
Eosinophilia - complications
Eosinophilia - therapy
Health technology assessment
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Pulmonary Eosinophilia - blood
Pulmonary Eosinophilia - therapy
Thrombotic Microangiopathies - complications
Thrombotic Microangiopathies - therapy
Thrombotic microangiopathy
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Summary:Abstract There are only a few cases in the literature that describe s the association between hypereosinophilic syndromes and thrombotic microangiopathy (TMA). Here we present the case of a man who suddenly developed a TMA in the context of eosinophilic pneumonia, who recovered successfully with six sessions of plasmapheresis and corticoids. Although the Pathophysiology is unknown, we hypothesize about the prothrombotic effects of the eosinophils. Also we describe a literature review.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2012.07.021