Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral anti...

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Bibliographic Details
Published in:Journal of neurovirology 2012-12, Vol.18 (6), p.532-537
Main Authors: Polledo, Laura, González, Jorge, Benavides, Julio, Martínez-Fernández, Beatriz, Ferreras, Ma. Carmen, Marín, Juan F. García
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - immunology
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood Vessels - immunology
Blood Vessels - pathology
Brain - immunology
Brain - pathology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
Encephalitis, Viral - immunology
Encephalitis, Viral - pathology
Encephalitis, Viral - veterinary
Human viral diseases
Immunohistochemistry
Immunology
Immunophenotyping
Infectious Diseases
Macrophages - immunology
Macrophages - pathology
Medical sciences
Neurology
Neurosciences
Sheep
Sheep, Domestic
Short Communication
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral diseases of the nervous system
Virology
Visna - immunology
Visna - pathology
Visna-maedi virus - immunology
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Summary:We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral antigen was detected in perivascular cuffs where CD8+ T cells predominated, but in severe lymphocytic lesions, sparse antigen was identified, and CD8+/CD4+ T cells appeared in a similar proportion in multilayer perivascular sleeves. In histiocytic lesions, vessels were surrounded by macrophages with abundant viral antigen, with CD8+/CD4+ T cells and B cells in the periphery. These results could reflect different stages of virus neuroinvasion and clarify the neuropathogenesis of Visna/maedi encephalitis.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-012-0131-0