Comparison of arterial and mixed venous blood glucose levels in hemodynamically unstable pigs: implications for location of a continuous glucose sensor

One of several unsolved challenges in the construction of an artificial endocrine pancreas (a system for automatically adjusting the blood glucose level) is the positioning of the glucose sensor. We believe the best positioning to be either intraarterial or in a central vein. It is therefore importa...

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Bibliographic Details
Published in:Acta diabetologica 2012-12, Vol.49 (6), p.489-491
Main Authors: Skjaervold, Nils K., Aadahl, Petter
Format: Article
Language:English
Subjects:
Animals
Arteries - chemistry
Biosensing Techniques
Biosensors
Blood Glucose - analysis
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - methods
Diabetes
Glucose
Hemodynamics - physiology
Hogs
Insulin
Insulin Infusion Systems
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Prostheses and Implants
Short Communication
Swine
Veins - chemistry
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Summary:One of several unsolved challenges in the construction of an artificial endocrine pancreas (a system for automatically adjusting the blood glucose level) is the positioning of the glucose sensor. We believe the best positioning to be either intraarterial or in a central vein. It is therefore important to know whether the glucose content in these blood locations is the same. We conducted a post hoc analysis of previously collected data from pigs exposed to gross inflammatory and circulatory stress. Paired arterial and mixed venous glucose values were compared with a mixed effects model. We found the blood glucose values from the arterial and mixed venous blood to be the same.
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-012-0394-1